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At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

2026 Summer Intern - Enzyme Technologies Chapter

We advance science so that we all have more time with the people we love.

Department Summary

The Enzyme and Protein Engineering (EPE) team is seeking a highly motivated intern to join our team with a primary focus on experimental protein science, computational protein analysis, and post-translational modifications (PTMs). This position offers hands-on laboratory experience in protein characterization and analytical techniques, combined with computational modeling and in-silico protein design. The successful candidate will work at the bench performing protein analytics, support enzyme engineering through computational predictions and molecular dynamics simulations, and contribute to the organization and automation of experimental data, helping to bridge laboratory science with computational analysis and data management systems.

This internship position is located in **Santa Clara, California, on-site.**

The Opportunity

+ Protein engineering & analytics tasked to assist with the design, expression, and purification of recombinant proteins - ELISA/SDS-PAGE/HPLC/Western Blot Etc.

+ Investigations of post-translational modifications such as glycosylation, phosphorylation, acetylation, and Ubiquitination using fluorescence based and MassSpec based assays

+ Protein In-Silico & Computational Modeling, assist with rational protein structure predictions utilizing molecular dynamic simulations and protein language models (GROMACS/ProtBERT)

+ Assist in developing tools for high-throughput data extraction, transformation, and storage

Program Highlights

+ **Intensive 12-week, full-time (40 hours per week) paid internship.**

+ **Program start dates are in May/June (Summer).**

+ **A stipend, based on location, will be provided to help alleviate costs associated with the internship.**

+ Ownership of challenging and business-critical projects.

+ Work with some of the most talented people in the biotechnology industry.

Who You Are

Required Education

You meet one of the following criteria:

+ **Must be pursuing a Bachelor's Degree (enrolled student)**

+ **Must be pursuing a Master's Degree (enrolled student).**

+ **Must be pursuing a PhD (enrolled student).**

Required mayors:

Biochemistry, Molecular Biology, BioEngineering, Bioinformatics, Computer Science, Data Science, or related field

Required Skills

+ Strong interest in protein sciences and post-translational modifications

+ Proficiency in Python and/or R for data analysis and automation

+ Basic understanding of protein structure and function

+ Excellent problem-solving and analytical skills

+ Strong communication skills and ability to work in cross-functional teams

Preferred Knowledge, Skills, and Qualifications

+ Prior laboratory experience in protein biochemistry or analytical chemistry

+ Prior experience in NGS sequencing applications and or data analysis

+ Familiarity with chromatography principles and mass spectrometry data formats

+ Experience with protein computational tools: Protein large language models (ESM, ProteinMPNN, AlphaFold), Molecular dynamics simulation packages (GROMACS)

+ Experience with automation tools and frameworks: API development (FastAPI), database management (SQL), Cloud platforms (BigQuery)

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of **California** is $26.00-$46.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (https://docs.google.com/forms/d/e/1FAIpQLSdZWlsbfQOvFVIQgHE\_iDzWUTlhZvj6FytIzjS7xq6IGh1H5g/viewform) .