• In-vitro Scientist II

    US Tech Solutions (South San Francisco, CA)


    General Position Summary/Purpose:

    + The **DMPK-BA** department is seeking a highly motivated fulltime DMPK Scientist to join the **In Vitro ADME** Sciences group (IVAS).

    + The successful candidate will work in collaboration with other team members to characterize the **CYP Induction** properties of **candidate drug molecules** and also may work on other **in vitro ADME assays. DMPK-BA** works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct **preclinical studies** , support clinical evaluation and contribute to **IND and NDA filings.**

    + In this role, you will be a scientist with hands-on experience in conducting **in-vitro ADME** assays primarily including **CYP450 induction** assays to characterize candidate drug molecules for potential to induce **CYP450 enzymes.**

    + Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.

    Core Job Responsibilities:

    + Routinely conduct (hands-on) evaluation of CYP450 induction

    + Conduct qPCR assay

    + Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems

    + Perform human hepatocytes cell culture, seeding and maintenance

    + Perform cell viability assessments and use microplate reader to measure endpoint

    + Contribute to invitro ADME assay design and discussions

    + Analyze data and maintain detailed, accurate and comprehensible study documentations

    + Use BioELN and GraphPad Prism for data analysis

     

    BS or MS in with 3-5 + (BS) Ph.D. with 0+ years with relevant exp. In their PhD program (Chemistry/Bio Chemistry)

    Top 5 skills

    1. CYP induction assay

    2. in vitro ADME

    3. qPCR

    4. Cell culture

    5. liquid handling system

    About US Tech Solutions:

    US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.

     

    US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.