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We are looking for an exceptional Physician Scientist to join our Cardiometabolic Therapeutic Area Genetics (TAG) team at the Regeneron Genetics Center (RGC). Within the RGC, the Cardiometabolic TAG team is using massive scale human exome sequencing for discovery and validation of new therapeutic targets in obesity and obesity associated metabolic disease. The position holder will collaborate with various RGC teams and with pre-clinical and clinical development teams at Regeneron to accelerate therapeutic development for genetically-validated targets in obesity and metabolic disease via the generation of new human genetics and epidemiological insights.

In this role, a typical day might include the following:

+ Accelerate therapeutic development for genetically-validated targets via the generation of new human genetics and epidemiological insights.

+ Generate key research questions and then design and execute studies and analyses to help address these questions, interpret the results of these studies and summarize ensuing insights in a variety of formats for different audiences (e.g. documents, presentations, patent applications, publications, etc.).

+ Understand and leverage RGC and Regeneron datasets, external resources and the scientific/medical literature to address key research questions at hand and summarize results giving appropriate weight to quantitative and qualitative strength of evidence.

+ Support target nominations and validation utilizing the RGC’s human genetics capabilities and leveraging Regeneron’s extensive internal therapeutics platforms and development modalities.

+ Partner with Clinical Development to evaluate clinical stage programs and opportunities for human genetics studies to aid in the selection of indications or evaluation of safety considerations.

+ Participate in the intellectual life of the Cardiometabolic TAG, the RGC and Regeneron at large and help build an inclusive work culture where everyone can perform at their best and fully develop their talent and potential.

+ Represent the Therapeutic Area Genetics team in cross-functional initiatives within RGC and Regeneron.

This job might be for you if you have:

+ Demonstrated ability to design and lead human genetics and epidemiological studies delivering medically-relevant findings in a team-based environment.

+ Ability to use medical knowledge to define relevant phenotypes for genetic association studies and to formulate innovative and important research questions. Familiarity with clinical genetics concepts and various genetic models of disease.

+ Strong computational and quantitative skills including ability to design and execute complex analyses using large scale datasets both with individual-level as well as result-level data (e.g. UK Biobank, All of US, MVP, Biobank Japan, meta-analysis of genome-wide summary statistics, etc). This includes proficiency with R or similar software and familiarity with high performance computing environments.

+ Experience leading complex human genetics research endeavors. Knowledge of different study designs and analyses including GWAS, exome or genome sequencing in cohort, case-control or family-based studies. Ability to integrate different data resources to translate initial findings.

+ Familiarity with the applications of genetics to gain medically-actionable insights including polygenic risk scores, quantitative traits analyses and Mendelian randomization.

+ Understanding of drug development and clinical trial design and execution. Experience as investigator in Randomized Controlled Trials is a plus. Experience in the clinical management or medical research relating to cardio-metabolic disease is not strictly required but is a plus.

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**To be considered for this role,** you must have a MD with strong background in and knowledge of human genetics and genetic epidemiology. An outstanding candidate will be an MD/PhD with training and experience in translational human genetics, genetic epidemiology, epidemiology (or related disciplines) and strong quantitative skills.

\#MDJOBSGG #MDJobs

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$173,500.00 - $283,100.00