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Job Title: Scientist IIJob Description

The Biologics Drug Product Development team is seeking a Scientist II to join our efforts in Lake County, IL. This onsite position is a 1-year contract with the potential for extension. Our team focuses on developing antibody drug conjugates (ADCs) and other biologics using cutting-edge formulation and analytical technologies. We aim to create valuable intellectual property through innovative formulation compositions, cost-effective manufacturing processes, and by preparing and defending CMC (Chemistry, Manufacturing, and Control) regulatory content. The successful candidate will support both developability and formulation development efforts, working closely with a global team and scientists from multiple functional areas including Discovery, Analytical, and Process R&D.

Responsibilities

+ Support the biologics characterization and stability assessment activities of assigned biologics, including candidate screening and selection for clinical studies and commercialization of monoclonal antibodies, antibody drug conjugates, bispecifics, and fusion proteins.

+ Execute studies evaluating the stability (chemical and physical) of biologics against solution conditions such as pH, ionic strength, temperature, and light, as well as physical stresses from manufacturing process conditions like freeze-thaw, mixing, filtration, filling, and lyophilization.

+ Screen excipients, buffers, stabilizers, surfactants, etc., to develop robust formulations for frozen, refrigerated, liquid, and lyophilized dosage forms.

+ Prepare concise and sound scientific presentations of experimental results to management and assist in authoring detailed scientific technical reports.

+ Stay current with scientific literature and support new scientific initiatives.

Essential Skills

+ Bachelor’s or Master’s degree in a scientific field with typically 4 years of relevant experience for a Bachelor's or 2 years for a Master's.

+ Extensive hands-on expertise using analytical methods for chemical and structural characterization of biologics, such as HPLC, UPLC, capillary electrophoresis, particle analysis, and other biophysical techniques (e.g., UV-vis, DLS, DSC) for protein characterization.

+ Scientific understanding of the structure-function of monoclonal antibodies, antibody constructs/conjugates, bispecifics, and fusion proteins, including their modes of degradation/stabilization.

+ Strong laboratory skills focused on formulation development for monoclonal antibodies and antibody constructs/conjugates, including standard and functional excipient selection and high-throughput assays.

+ Solid understanding of various unit operations of aseptic manufacturing, such as bulk freeze-thaw, compounding/mixing, filtration, filling, and lyophilization for liquid and lyophilized NBEs.

Additional Skills & Qualifications

+ Builds strong relationships with peers and cross-functionally with partners outside of the team to enable higher performance.

+ Excellent oral communication skills in a scientific setting, as well as sound technical writing and documentation competencies.

+ Ability to work independently, respond to changing priorities, and manage short lead times for multiple tasks.

+ Capability to identify problems and work toward solutions.

+ Embraces innovation and creates a learning environment open to suggestions and experimentation for improvement.

Work Environment

This position is based in Lake County, IL, and requires onsite presence. The work involves collaborating with a global team and scientists from various functional areas, utilizing state-of-the-art technologies and methodologies in biologics drug product development. The environment fosters innovation and continuous learning, providing opportunities for professional growth and development.

Pay and Benefits

The pay range for this position is $50.00 - $55.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: • Medical, dental & vision• Critical Illness, Accident, and Hospital• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available• Life Insurance (Voluntary Life & AD&D for the employee and dependents)• Short and long-term disability• Health Spending Account (HSA)• Transportation benefits• Employee Assistance Program• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in North Chicago,IL.

Application Deadline

This position is anticipated to close on May 9, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email [email protected] (%[email protected]) for other accommodation options.