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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our Lilly Genetic Medicines (LGM) team is an innovation-focused organization striving to identify, develop and apply the most groundbreaking technologies to deliver maximum benefit to our patients. Our agile and diverse team strives to operate as an autonomous ‘biotech-like’ company within the walls of Lilly.

Our rapidly expanding Lilly Genetic Medicines (LGM) in Indianapolis is seeking to grow our in vivo pharmacology capabilities. Our team works cross-functionally with multiple therapeutic modalities and the ideal candidate for this position will help support efforts in diverse genetic medicines and targets. Our goal is to deliver on the promise of durable genetic medicines to patients. This position will be based in Indianapolis, IN and located at Lilly Corporate Center.

The Associate Scientist, In Vivo Pharmacology, will participate and contribute to the in-vivo pharmacology lab, to support the discovery and optimization of novel therapeutic candidates for genetic medicines.

Overall Responsibilities** **:

+ Work with project team leads to design and plan in vivo experiments to support the preclinical characterization and evaluation of novel therapeutic molecules.

+ In vivo skills in rodents: animal handling, dosing (ICV, IV, IM, SC, IP, etc), brain microdissection and organ harvest, transcardial perfusion, blood and CSF collection.

+ Analyze and interpret experimental data, ensuring accuracy and reproducibility.

+ Maintain documentation practices that align with both local and regulatory guidelines.

+ Accurate recording of all practical work: completion of electronic notebook to Lilly procedure quality standards

+ General laboratory assistance, including ordering and receiving lab supplies, preparing reagents, and maintaining laboratory equipment

+ Ensure compliance with all health and safety regulations

+ Communicate research results in a clear and concise manner to team members and larger cross-functional teams in both reports and data presentation formats.

+ Collaborate with team members to develop and evolve understanding of RNA-based therapeutic strategies.

+ Stay current with the latest advancements in RNA biology and pharmacology.

+ Demonstrate high learning agility to incorporate new scientific concepts and methods into research.

Basic Qualifications:

+ Bachelors and/or Masters Degree in Biology, Molecular Biology, Pharmacology, Biochemistry, or related scientific fields with 1+ years of relevant in vivo work experience (academic or industry)

Additional Skills/Preferences:

+ Strong background in biology, with a preference for RNA biology

+ Expert in vivo skills including rodent handling, dosing (IV, SC, IP, , etc.)

+ Experience conducting RNA extraction from tissues and RT-qPCR is strongly preferred

+ Candidates with experience doing microdissection or surgery, or stereotaxic surgery are preferred

+ Prior experience in macromolecule distribution and metabolism

+ Experience with ex-vivo assays is a plus such as ELISAs, WB, qPCR and histology techniques

+ Experience introducing exogenous genes in rodents via AAV or HDI is a plus.

+ Experience with RNA therapeutics and pre-clinical drug pharmacology

+ Experience isolating primary cells from tissues is a plus

+ Proven track record of scientific publications

+ Strong analytical thinking skills. Demonstrated ability to articulate issues, and extract and synthesize complex issues into a key focus

+ Strong interpersonal and communication skills. Proven record to collaborate and network across a wide variety of functions and work effectively with internal and external partners

+ Excellent organizational skills with the ability to work in a fast-paced team environment, meet deadlines, maintain detailed documentation, and prioritize work on multiple projects

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$63,000 - $162,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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