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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Protein Biosciences group at the Lilly Biotechnology Center in San Diego is seeking a motivated and detail-oriented mass spec scientist to join our Protein Mass Spectrometry Laboratory in Antibody Discovery. The successful candidate will contribute to the characterization of therapeutic proteins using state-of-the-art LC/MS systems as well as various stability indicating assays. This position is ideal for someone with a strong foundation in protein biochemistry and hands-on experience in an analytical mass spec laboratory.

Responsibilities:

+ Develop and perform LC-MS and LC-MS/MS analyses of bispecific antibodies, antigens, fusion proteins, peptides, conjugates, and other biologics.

+ Execute intact mass, clipping analysis, peptide mapping, disulfide bond mapping, and host cell analyses independently. Support structural elucidation and product characterization.

+ Develop and conduct antibody based stability study and serum stability study using mass spec, cIEF, CE-SDS, labchip, HPLC (SEC, CEX, AEX), and related biophysical techniques.

+ Perform high-throughput (HT) analytical screening assays using Hamilton and other automated liquid handler systems for sample preparation.

+ Operate, calibrate, and maintain LC and LC/MS systems (e.g., Agilent Q-tof and Tof, Thermo High Resolution MS systems) and other analytical instruments (MAURICE, nanodrop, Lunatic)

+ Document experimental results in electronic lab notebooks (ELN) and contribute to technical reports and presentations.

+ Collaborate with cross-functional teams including protein engineering, computation, and various discovery groups.

Basic Qualifications:

+ A PhD degree in biology, chemistry, biochemistry, or a similar field with a minimum of 1-3 years of relevant industry experience (Post-Doc experience accepted).

+ Must have strong method development skills in mas spec, CE-SDS, and cIEF

Additional Skills and Preferences:

+ **Must have experience with GeneData Expressionist data processing.**

+ Highly organized, detail-oriented, and self-motivated.

+ Strong communication and presentation skills with a collaborative mindset.

+ Willingness to learn and grow in a dynamic and fast-paced discovery team.

+ Experience with sample preparation for MS analysis of proteins and peptides.

+ Working knowledge of chromatography and Agilent and Thermo MS instrumentation.

+ Must be familiar with Agilent Q-Tof, Thermo QE, Exploris 480, and Waters Cyclic IMS

+ Must have a strong understanding of protein/antibody structure and post-translational modifications

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$133,500 - $217,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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