• Senior Medical Director

    Astrix Technology (Boston, MA)


    Senior Medical Director

     

    Clinical Data Management

     

    San Diego, MA, US

    Pay Rate Low: 220000 | Pay Rate High: 250000

    + Added - 15/05/2025

     

    Apply for Job

     

    Onsite

     

    Salary: $220,000-$250,000

    Key Responsibilities

    Therapeutic Area & Strategic Leadership

    + Act as the Senior Medical Director for hypertrophic cardiomyopathy (HCM), advancing the clinical development strategy for Antisense Oligonucleotide RNA-based therapeutics and precision RNA medicine.

    + Translate insights from RNA science and translational research into clinical execution, partnering with RNA scientists, biomarker teams, and patient stratification experts to support personalized treatment approaches.

    + Collaborate across departments to drive the HCM RNA therapeutics portfolio, ensuring alignment with company goals and scientific vision.

    + Guide the implementation of clinical plans leveraging state-of-the-art RNA technologies to pioneer novel HCM therapies.

    Clinical Development & Medical Oversight

    + Lead the design of clinical trials, shaping protocols and embedding precision RNA methodologies into endpoints and study frameworks.

    + Serve as medical lead and monitor for early-phase studies, including first-in-human trials, ensuring thorough safety and efficacy evaluations.

    + Contribute to biomarker strategy and validation, including RNA biomarkers, genomics, proteomics, and imaging technologies, to assess disease progression and treatment response.

    + Ensure regulatory compliance for clinical trials and provide medical expertise in preparing INDs/CTAs and other core documentation.

    Cross-Functional Collaboration & Thought Leadership

    + Align clinical development with company-wide strategies through close collaboration with preclinical, clinical operations, biomarker, and regulatory teams.

    + Represent in clinical advisory boards, steering committees, and data safety monitoring boards (DSMBs) as an expert in RNA therapeutics and HCM.

    + Engage with key opinion leaders (KOLs) and external experts to validate and refine clinical strategy.

    + Stay abreast of scientific advancements in RNA therapeutics, HCM, and precision medicine; disseminate key findings internally to guide decision-making.

    Regulatory Strategy & Documentation

    + Contribute to the regulatory strategy, ensuring alignment with FDA, EMA, and other global health authorities for pipeline assets.

    + Support the development and review of regulatory filings, including INDs, CTAs, and clinical trial documentation related to RNA-targeting therapies.

    Education & Experience

    + MD or MD/PhD with a focus in cardiovascular clinical development, RNA therapeutics, or a related discipline.

    + At least 10 years of experience in basic and/or translational cardiovascular research, including substantial work in HCM or similar conditions.

    + Proven track record leading clinical programs in genetic or RNA-based therapeutics.

    + Board certification (or equivalent experience) in Cardiovascular Diseases, Advanced Heart Failure, Genetic/Familial Cardiomyopathy, or HCM preferred. **_This job description is a complete list of all desired skills but not all are required. We strongly encourage candidates who have some of the skills to apply. We look forward to a conversation to learn more about you!_** **_INDBH_**

     

    We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.