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Job Description

Our large pharmaceutical client is seeking a Sr. Principal Scientist, Cellular & Mechanistic Pharmacology to join as a direct FTE in Spring House, PA.

Purpose: The Discovery Technologies & Molecular Pharmacology (DTMP) team within Therapeutics Discovery contributes to the progression of drug discovery projects from target identification to clinical development. We're looking for a talented scientist with an immunology background, deep expertise in disease biology and cellular pharmacology, and a passion for finding innovative therapeutics to treat diseases with high unmet medical need.

Key Responsibilities:

• Lead development of innovative cell-based assays for immunology-focused projects to identify and evaluate targets, and to progress hits and lead molecules.

• Act as a key liaison between DTMP and program teams, driving project strategy and execution, in partnership with cross-functional colleagues.

• Lead efforts to combine translational and mechanistic assays with biosignature approaches and novel AI/ML methods to reveal new biology and pharmacology.

• Manage and mentor lab scientists and contribute to the cellular and mechanistic pharmacology portfolio.

• Analyze and present data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals.

We are a company committed to creating inclusive environments where people can bring their full, authentic selves to work every day. We are an equal opportunity employer that believes everyone matters. Qualified candidates will receive consideration for employment opportunities without regard to race, religion, sex, age, marital status, national origin, sexual orientation, citizenship status, disability, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or recruiting process, please send a request to Human Resources Request Form (https://airtable.com/app21VjYyxLDIX0ez/shrOg4IQS1J6dRiMo) . The EEOC "Know Your Rights" Poster is available here (https://www.eeoc.gov/sites/default/files/2023-06/22-088\_EEOC\_KnowYourRights6.12ScreenRdr.pdf) .

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Skills and Requirements

-Minimum of Ph. D. in Immunology, Cell Biology or equivalent with post-doctoral experience and a minimum of 10 years of experience developing and applying novel cellular assays in a pharmaceutical industry/biotech setting

-Proven track record in managing immunology-focused drug discovery programs across diverse modalities, in an industry setting.

-Deep expertise and proven accomplishments in de novo immunology cellular pharmacology assay development, complex immune cellular models and high-throughput technology platforms.

-Experience with generating and culturing translationally relevant cell models such as iPSC-derived cells, primary cells, and/or co-cultures.

-Expertise collecting and analyzing data using high dimensional approaches such as high content imaging, flow cytometry and/or RNAseq.

-Strong experience as a leader, problem solver and team collaborator able to facilitate understanding between biologists, chemists, and data scientists.

-A demonstrated ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications. -Expertise in assay automation.

-Proficiency with CAS/CRISPR, lentivirus and/or RNAi approaches.

-Expertise developing assays in advanced 3D cell models.

-Expertise in neuroscience and/or oncology therapeutic areas.

-Experience working with and/or guiding external collaborators in industry or academia. null

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal employment opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment without regard to race, color, ethnicity, religion,sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military oruniformed service member status, or any other status or characteristic protected by applicable laws, regulations, andordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to [email protected].