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Job Title: Downstream Processing TechnicianJob Description

The candidate will support the performance of operations in the manufacture of Commercial and Clinical Biologics. They will follow Current Good Manufacturing Practices (cGMPs) and carry out a variety of functions related to Downstream (purification and filtration/HPLC). These functions may include activities such as propagation of mammalian cell culture, conducting aseptic cell culture operations, execution of large-scale production bioreactors (50L - 2000L), and conducting large scale filtration or centrifugation. Purification will be handled through large scale chromatography (column and HPLC).

Responsibilities

+ Review all area documents.

+ Assist in the manufacture of controls and calibrators and complete batch records following cGMPs.

+ Perform in-process assays using equipment such as spectrophotometers, pH meters, and clinical analyzers.

+ Weigh, transfer, and mix chemicals as required.

+ Perform product filtrations.

+ Clean and steam steel tanks (CIP/SIP).

+ Prepare glassware and steel tanks for sterilization in autoclave and operate autoclave.

+ Maintain lab equipment including pumps, pH meters, and flow meters.

+ Keep department lead or manager updated on all issues.

+ Monitor stocks of common lab supplies.

+ Perform other job duties as required.

+ Respond to emergency notifications.

+ Work flexible hours, including weekends.

Essential Skills

+ Minimum of 2 years of work experience in manufacturing, operation, production, lab setting or related field.

+ Knowledge of cGMP practices, aseptic techniques, or chemical concepts.

+ Experience with cleanroom environments and aseptic techniques.

Additional Skills & Qualifications

+ Preferred: Experience in a cGMP environment and a 4-year STEM degree.

+ Subject Matter Expert on downstream processing steps.

+ Bachelor's Degree in Science with aseptic technique, chemistry, HPLC, Pharmaceutical, Pharmaceutical industry, bioreactor.

Work Environment

Clean room/aseptic suites - Must be willing to gown up. Rotating 12-hour shifts, working 7 days out of a 2-week period. Shifts include 1 DAY Shift: 6:15am-6:45pm and 1 NIGHT Shift: 6:15pm-6:45am. Be willing to wear a full gowning suit which includes: bodysuit, gloves, hair & beard nets, face covers, and safety glasses. Able to meet clean room gowning requirements, including wearing Tyvek, Nitrile, and/or Latex gloves. Ability to lift a minimum of 25 lbs independently and stand for 80% of the shift.

Pay and Benefits

The pay range for this position is $27.00 - $31.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: • Medical, dental & vision• Critical Illness, Accident, and Hospital• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available• Life Insurance (Voluntary Life & AD&D for the employee and dependents)• Short and long-term disability• Health Spending Account (HSA)• Transportation benefits• Employee Assistance Program• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Saint Louis,MO.

Application Deadline

This position is anticipated to close on May 30, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email [email protected] (%[email protected]) for other accommodation options.