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The Center for Immuno-Oncology (CIO) is seeking an experienced Research Operations Manager to oversee daily laboratory operations in the collection, processing and storage of patient biospecimens for research.

The CIO is a multi-disciplinary group dedicated to the discovery of novel biomarkers in clinical trials and clinical studies related to cancer immunotherapies spanning many different tumor types. The CIO’s Immune Assessment Laboratory (IAL) aims to provide researchers with access to the latest innovations in blood immune-monitoring in a quality-controlled setting (https://cioial.dana-farber.org/). Key laboratory techniques to study immune cell populations in peripheral blood mononuclear cells (PBMCs) include mass cytometry (CyTOF) and spectral flow cytometry (FACS), while proteomic cytokine detection methods such as Olink and Luminex are applied to plasma and serum. Importantly, the IAL are also involved in the collection of blood from patients participating in more than 50 clinical trials at DFCI and multiple external sites.

The Research Operations Manager (ROM) will work onsite daily in close partnership with the Leader of the IAL to direct the blood biobanking efforts for clinical trials and research collection protocols. They will oversee the entire biospecimen lifecycle, including patient sample collection, processing, storage, retrieval, distribution, inventory management, and regulatory compliance. The role will work collaboratively in communicating with multiple clinical research teams, laboratories, other biorepositories and vendors to ensure efficient and accurate specimen handling. The ROM will lead the implementation of new biospecimen management tools to ensure accurate tracking of biospecimens and their data. Furthermore, they will help direct the Luminex and Olink proteomics platforms and support scientific collaborations with academic and industry partners. The successful ROM candidate will play a pivotal role in laboratory administration, with a strong focus on efficiency and quality control, training of staff, and daily problem-solving to efficiently co-ordinate research operations and biospecimen management.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

+ Institute, maintain, and improve laboratory standard procedures

+ Responsible for efficient inventory, maintenance and ordering

+ Responsible, directly or indirectly, for clinical samples processing, scheduling and banking

+ Responsible, directly or indirectly, for care, repair and maintenance of laboratory equipment, including liquid nitrogen tanks

+ Ensure good laboratory practice through training and guidance of technicians and trainees

+ Arrange core seminars for research staff

+ Responsible for managing efficient administration of research materials/stocks

+ Responsible for distribution and cataloguing of laboratory notebooks

+ Assist lab supervisors with teaching, training, mentoring, orientation, in-service and continuing education for laboratory staff and trainees.

+ Ensures all lab staff are compliant with DFCI and sponsor mandatory trainings.

+ Perform protein detection techniques such as Olink, Luminex, Mass cytometry and flow cytometry

+ Bachelor degree in Biology or a healthcare related science is required, ideally with experience in immunology, oncology, or biomedical laboratory settings.

+ 3-5 years of research management required.

+ Relevant experience in clinical research, including human biospecimen management and handling is required.

+ Experience with human immune cell processing, banking, and biospecimen storage systems preferred

+ Experience in management or mentoring of staff within a small or medium size research laboratory in the field of biomedical sciences is preferred.

+ Familiarity with cancer research laboratory operations including equipment maintenance, safety, compliance, and record keeping is preferred

+ Exceptional people and organization skills, with demonstrated ability to multi-task to enable many concurrent projects in a complex, fast paced environment.

+ Excellent quantitative, analytic, and problem-solving skills to evaluate all aspects of a problem and make or facilitate appropriate and timely decisions.

+ Excellent interpersonal skills, including the ability and willingness to work closely with other colleagues as a team; experience and comfort in working with individuals with diverse backgrounds and differing viewpoints; openness to new ideas.

+ Proficiency in Word, Excel, PowerPoint.

+ Flow cytometry experience and data analysis with FlowJo (preferred)

+ ELISAs type assays experience (preferred)

+ Keep regular, detailed and accurate documentation of lab activities

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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