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*Summary *

The work consists of using genetically engineered mouse models to understand the mechanisms that underlie lung cancer tumorigenesis and response to therapy. Mice will be bred into appropriate genotypes, monitored and followed for tumor burden, and tumors will be harvested for evaluation of clinical and biochemical characteristics. Western blot, immunohistochemistry, and histological analyses will also be performed. Experiments will be designed, executed, analyzed and experimental results written for publication in peer-reviewed journals and presentation at international meetings. The person will also provide technical training and supervision for other junior laboratory members, including summer and graduate students within the Department of Genetics. And finally, this person will help manage key collaborations relating to their projects.

*Key Functions *

*1. Independent Project(s) *

The instructor will conduct research involving the organismal control of lung cancer initiation and therapeutic response using genetic or environmental exposure-based models (including radon gas and air pollution or PM 2.5 ). The instructor will use genetics and multi-omics to study the mechanisms by which cancer initiation and progression pathways are controlled at different levels. More specifically, will perform a series of experiments to start addressing the various molecular mechanisms by which different lung or microenvironment cells communicate among each other and potentially with cells directly involved in various responses. It is expected that independent projects will account for roughly 85% of the time of the instructor.

*2. Laboratory Techniques *

The above projects will require performing standard protocols in molecular biology, cell biology, and the generation of mouse models that will include isolation of DNA and RNA, agarose and polyacrylamide gel electrophoresis, DNA sequencing and sequence analysis, cloning, enzymatic manipulation, PCR, cell culture, Western blogging, immunofluorescence, propagation and analysis of mouse mutants, preparation of DNA for WGS seq, and of RNAs for single cell or bulk RNA seq experiments, etc. Prior expertise in the above described scientific approaches is required. Requires an advanced knowledge in the proper handling of hazardous chemicals. The handling of potentially toxic materials should be in accordance with OSHA and institutional safety policies.

*3. Organization Duties*

Responsible for oversight and maintenance of laboratory equipment required for performing the project. Responsible for ensuring compliance with state/federal and institutional guidelines in storage, use and disposal of hazardous chemicals used in the performance of research duties. It is expected that the laboratory maintenance and supervision will not take more than 5% time of the Instructor.

*4. Communication Skills*

Must be fluent in written and spoken English. Must be able and willing to convey experimental results clearly to the supervisor and other laboratory personnel, and instruct new laboratory members in experimental methods. Will be expected to present research results at institutional, national and international forums, where appropriate. Must be able to write and complete a quasi final form of any scientific paper that result from research conducted by the instructor. All communication in any mode must be thoroughly professional.

*5. Computer Operation and Management *

Advanced computer proficiency needed in using a PC or Macintosh personal computer or other Unix-based systems for word processing, figure generation and the generation and storage of data and laboratory records. Must be knowledgeable in accessing computer databases and be willing and able to learn new computer programs when necessary and where applicable.

*6. Performs Other Duties as Required *

This position has a target base salary of $65,000 to $80,000 and is eligible for incentive compensation, comprehensive health, wellness, time off, savings, and retirement benefits, as well as relocation support, as applicable.

*Education *

Required: Ph.D. degree in related field of science

*Experience *

Required: Five years of research laboratory experience in molecular and cell biology as it relates to the study of neural-immune communication with a Ph.D. degree in one of the sciences.

Preferred: Experience gained at The University of Texas M.D. Anderson Cancer Center

*Licensure/Certification *

Preferred: None

*Other *

Position requires long stretches of time working at laboratory. Must manually operate laboratory equipment as necessary to fulfill completely all essential functions described above, including but not limited to centrifuges, balances, incubators, microscopes, and power supplies. Research techniques require good eye-hand coordination and manual dexterity to complete tasks, as well as visual acuity to analyze results. Position will require exposure to and working with radioactive materials, biohazards, and hazardous chemicals. Position will require excellent math skills, documentation techniques, time management and organizational techniques in routine duties.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

Additional Information

* Requisition ID: 174944

* Employee Status: Regular

* Minimum Salary: US Dollar (USD) 0

* Midpoint Salary: US Dollar (USD) 0

* Maximum Salary : US Dollar (USD) 0

* FLSA: exempt and not eligible for overtime pay

* Work Location: Onsite

* Science Jobs: Yes

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