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At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Position Overview:

We are seeking a highly motivated and creative Principal Scientist to lead our Lipid Nanoparticle (LNP) technology advancement within the Discovery Sciences and Technologies (DST) Department. This pivotal role will enable and drive innovation in LNP-based drug delivery across Virology, Oncology, and Inflammation therapeutic areas.

DST Department members are responsible for the design and execution of rigorous, quantitative, and physiologically relevant in vitro biochemical and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from lead identification efforts during project inception to the characterization of the final development candidate.

The successful candidate will be an integral senior member of a high performing research core team dedicated to LNP-based discovery research for therapeutic applications while also establishing strategic partnerships and driving scientific innovation. This individual will work closely with various research functions and external collaborators to advance transformational nucleic acid-based therapies into clinical development for patients.

Our company is a highly matrixed organization and the ability to work effectively across diverse functional groups and therapeutic areas is a key attribute for this role.

Specific Responsibilities:

+ Develop and implement a comprehensive scientific strategy for LNPtechnology advancement aligned with therapeutic area objectives and priorities

+ Build and lead a high-performing team of LNP scientists,establishing priorities, allocating resources, and ensuring milestoneachievement across multiple projects.

+ Design and optimize novel LNP formulations incorporating diversenucleic acid cargos.

+ Establish and validate an array of analytical methods for comprehensiveLNP characterization including size distribution, charge, morphology,encapsulation efficiency, and stability profiling.

+ Develop and execute cell-based screening to evaluate andoptimize delivery efficiency and cellular tropism.

+ Design and coordinate in vivo studies in collaboration withtherapeutic areas to assess biodistribution, pharmacodynamics, andefficacy of LNP formulations.

+ Identify, establish, and manage strategic external collaborationswith academic institutions and biotech companies to advance LNPtechnology capabilities.

+ Provide scientific leadership in problem-solving complex formulationchallenges and troubleshooting LNP development issues across multipleprojects.

+ Contribute to the preparation of scientific reports, manuscripts, and patent applications.

Minimum Qualifications:

+ Ph.D. in Pharmaceutical Sciences, Chemical Engineering,Biochemistry, or related field.

+ 10+ years of research experience in lipid nanoparticle formulationand development for nucleic acid therapeutics.

+ Minimum 3 years in a managerial role with demonstrated teammanagement experience.

+ Proven track record of publications and/or patents in LNP based technologies and/or other drug delivery systems.

+ Deep expertise and extensive hands on experience in lipid chemistry, purification, bioconjugation and characterization techniquesincluding DLS, zeta potential, HPLC, transmission electron microscopy, and flow cytometry.

+ Demonstrated ability to design and execute in vitro and in vivostudies for LNP evaluation and optimization.

+ Familiarity with additional in-vivo delivery platforms would be advantageous

+ Proficiency in data analysis tools and statistical software;experience with AI/ML applications in drug formulation optimization isa plus.

+ Exceptional problem-solving abilities and scientific judgment incomplex formulation challenges.

+ Strong project management skills with ability to oversee multipleprojects simultaneously while maintaining high quality standards.

+ Excellent verbal and written communication skills with the abilityto influence and collaborate effectively across disciplines andpresent to executive leadership.

The salary range for this position is: $195,670.00 - $253,220.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

For jobs in the United States:

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact [email protected] for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' (https://www.eeoc.gov/employers/eeo-law-poster) poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT (http://www.dol.gov/whd/regs/compliance/posters/eppac.pdf)

YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

PAY TRANSPARENCY NONDISCRIMINATION PROVISION (https://www.dol.gov/sites/dolgov/files/OFCCP/pdf/pay-transp\_%20English\_formattedESQA508c.pdf)

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please apply via the Internal Career Opportunities portal in Workday.

Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.