• Postdoctoral Scholar - Research Associate

    University of Southern California (Los Angeles, CA)


    Postdoctoral Scholar - Research AssociateApply (https://usc.wd5.myworkdayjobs.com/ExternalUSCCareers/job/Los-Angeles-CA---Health-Sciences-Campus/Postdoctoral-Scholar---Research-Associate\_REQ20163273/apply) Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences Los Angeles, California

     

    The Cogan Laboratory at the University of Southern California (USC) Alfred E. Mann School of Pharmacy is seeking a highly motivated postdoctoral researcher to investigate the mechanisms of modular polyketide and nonribosomal peptide biosynthesis. The selected individual

     

    will use biochemical and biophysical techniques, including single-particle cryogenic electron microscopy (cryo-EM), to understand the

     

    relationships between megasynthase structure and catalysis. The work entails additional opportunities to explore (1) the enzymology of as-yet

     

    undiscovered natural products and (2) mechanisms of bacterial signal transduction by sensor histidine kinases.

     

    Available Instrumentation: USC maintains >90 research core facilities, including a recently established state-of-the-art Cryo-EM Facility at the

     

    Core Center of Excellence in Nano Imaging (CNI). Cryo-EM resources include:

     

    1. Thermo Scientific Titan Krios G3i equipped with a GIF Quantum energy filter and K3 detector

    2. Thermo Scientific Glacios equipped with a Falcon 4 detector

    3. Thermo Scientific Vitrobot in a humidity-controlled room

    4. Essential tools for cryo-TEM grid preparation and storage

     

    High-performance computing resources for cryo-EM data handling/processing (e.g., Relion and cryoSPARC) are provided by USC's Center

     

    for Advanced Research Computing.

     

    Qualifications: Candidates must hold a Ph.D. in Chemistry, Biochemistry, Biophysics, Structural Biology, Chemical Biology, Medicinal

     

    Chemistry, or a related field. All qualified candidates will be considered, although preference will be given to those with experience in protein

     

    purification, structural biology, and/or molecular biology.

     

    Interested candidates should send their CV and a list of three references to Dillon Cogan at [email protected].

     

    The annual salary for this position is $68,640. When extending an offer of employment, the University of Southern California considers

     

    factors such as (but not limited to) the scope and responsibilities of the position, the candidate’s work experience, education/training, key

     

    skills, internal peer equity, federal, state, and local laws, contractual stipulations, grant funding, as well as external market and organizational

     

    considerations.

     

    Qualifications: Candidates must hold a Ph.D. in Chemistry, Biochemistry, Biophysics, Structural Biology, Chemical Biology, Medicinal Chemistry, or a related field. All qualified candidates will be considered, although preference will be given to those with experience in protein purification, structural biology, and/or molecular biology.

     

    REQ20163273 Posted Date: 06/02/2025