"Alerted.org

Life Science Research Professional 2 (Fixed-Term Position - 24 Months)

School of Medicine, Stanford, California, United States

Research

Post Date Jun 18, 2025

Requisition # 106695

The Division of Cardiovascular Medicineis a dynamic and innovative center dedicated to excellence in research, medical education, and clinical care. Our division is driven by over 80 faculty, clinician educators and instructors who are the pillar of strength in the Division's ongoing efforts into the prevention and treatment of cardiovascular disease. The Division of Cardiovascular Medicine inthe Department of Medicineseeks a Life Science Research Professional (LSRP) 2 forthe Quertermous Labin the Falk Cardiovascular Research Center.

The Quertermous laboratory employs genomic and genetic methods, such as HiChIP, ATAC-seq, and ChIP-seq to identify and annotate epigenetic mechanisms upstream of causal regulatory variations that we and our collaborators have identified in large scale human genome wide association studies. In addition, our interest in CAD-associated transcription factors that are active in the blood vessel wall has led us to integrate single cell technologies into our studies. The depth of data that single cell technologies has provided allows us to characterize the gene regulatory program mediated by these transcription factors as well as the transcriptional mechanisms by which these factors modulate cell state changes.

The Quertermous lab is seeking a highly motivated LSRP to play a central role in the development and implementation of an in vivo perturb sequencing project. The goal of this project is to study CAD-associated transcription factors involved in the process of atherosclerosis by inhibiting their function in smooth muscle cells of the blood vessel wall in a mouse model of atherosclerosis. The successful candidate will have experience in the study of transcriptional regulatory mechanisms and cell biology and interest in cardiovascular disease. Interest in and experience with genetic and genomics computational methods is highly desirable.

The LSRP will perform day-to-day experiments most often utilizing mouse genetic models, cell culture, and molecular biology techniques to accomplish the goals of the lab. This work will require the maintenance of a mouse colony representing a variety of genetic mutations. S/he is expected to have some expertise in dissection of mouse, frozen sample preparation and sectioning for histology. S/he will be expected to collect, analyze, and present research data to the research group. The LSRP will be expected to troubleshoot existing protocols and develop novel protocols and procedures and provide technical and scientific advice to other research personnel in lab. Duties will also include occasional preparation of DNA, RNA, and proteins from human and animal samples and downstream assays including qPCR, Western blots, and ChIP assays. S/he will have excellent communication and organizational skills. S/he must be able to work well independently and within a diverse team.

This is a twenty-four-month fixed-term position.

Duties include:

+ Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.

+ Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.

+ Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.

+ Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.

+ Participate in multidisciplinary teams across different faculties or schools.

+ Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.

+ Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.

DESIRED QUALIFICATIONS:

+ Doctoral degree (PhD, MD) in related scientific field

+ 3 years of relevant work experience

+ Proficiency with molecular biology techniques, such as luciferase reporter assays, western blot, immunofluorescence, real time PCR

+ Experience with mammalian tissue culture techniques

+ Experience with in vivo techniques, such as small animal surgery, tissue sampling and histological stains

+ Experience with CRISPR techniques

EDUCATION & EXPERIENCE (REQUIRED):

+ Bachelor's degree in related scientific field and two years of relevant work experience; or Master’s degree in a related scientific field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

+ Comprehensive understanding of scientific principles.

+ General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.

+ Strong analytical skills and excellent judgment.

+ Ability to maintain detailed records of experiments and outcomes.

+ Ability to work under deadlines with general guidance is essential.

+ Excellent organizational skills and demonstrated ability to accurately complete detailed work.

CERTIFICATIONS & LICENSES:

+ None

PHYSICAL REQUIREMENTS*:

+ Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.

+ Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.

+ Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.

+ Must have correctible vision to perform duties of the job.

+ Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.

+ Ability to lift heavy objects weighing up to 50 pounds.

+ Ability to work in a dusty, dirty, and odorous environment.

+ Position may require repetitive motion.

WORKING CONDITIONS:

+ May require working in close proximity to blood borne pathogens.

+ May require work in an environment where animals are used for teaching and research.

+ Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.

+ Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

+ May require extended or unusual work hours based on research requirements and business needs.

WORKING STANDARDS:

+ Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.

+ Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.

+ Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University’s Administrative Guide, http://adminguide.stanford.edu/.

The expected pay range for this position is $81,130 to $94,895 per annum.

Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford’s extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.

Why Stanford is for You

Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture andunique perksempower you with:

+ **Freedom to grow.** We offer career development programs, tuition reimbursement, or audit a course. Join a TedTalk, film screening, or listen to a renowned author or global leader speak.

+ **A caring culture.** We provide superb retirement plans, generous time-off, and family care resources.

+ **A healthier you.** Climb our rock wall or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits.

+ **Discovery and fun.** Stroll through historic sculptures, trails, and museums.

+ **Enviable resources.** Enjoy free commuter programs, ridesharing incentives, discounts and more.

_Consistent with its obligations under the law, the University will provide reasonable accommodations to applicants and employees with disabilities. Applicants requiring a reasonable accommodation for any part of the application or hiring process should contact Stanford University Human Resources by submitting acontact form._

_Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law._

_The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned._

Additional Information

+ **Schedule: Full-time**

+ **Job Code: 4952**

+ **Employee Status: Fixed-Term**

+ **Grade: G**

+ **Requisition ID: 106695**

+ **Work Arrangement : On Site**