"Alerted.org

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.

+ Candidate will join a very productive lab investigating the cause of permanent neurological disability in multiple sclerosis. Studies are clinically relevant. Interactions with MS physicians and MRI imaging scientists abundant. Primary sfocus will be on the role of dura associated lymphatics (DALT) and skull bone marrow in causing a surafce-in gradient of cortical atrophy in MS. Experience in working with postmortem brain tissue, rodents models transcriptomics, bioinfomatics and high resolutions confocal microscopy helpful.

**Principal Investigator:** Bruce D Trapp, PhD

**Lerner Research Institute Department:** Neurosciences

Lab Research Topics:

+ Cause of Permanent Neurological Disability in Multiple Sclerosis

+ Innate Immunity in MS

+ Role of DALT and skull bone marrow in MS

+ Bioinfomatics

+ Spatial Transcriptomics

+ For more information about the lab's research, please contact Dr. Trapp at [email protected] .

Job** **Responsibilities:

+ Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation

+ Primary lead in externally funded research project

+ Performance of high resolution confocal microscopy

+ Generation and analyses of transcript profiles

+ Writing publications as first author

Education:

+ PhD or MD/PhD required

+ MD with relevant laboratory experience may substitute for PhD

Languages:

+ English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

+ Previous experience in a research or academic setting. Graduate student experience meets this requirement.

+ Scientific writing experience

Additional Preferred Qualities:

+ Hard working and dedicated

+ Good communication skills

+ Team player

+ Goal directed

+ Good writing skills

Physical Requirements:

+ Ability to perform work in a stationary position for extended periods

+ Ability to operate a computer and other office equipment

+ Ability to communicate and exchange accurate information

+ Ability to distinguish color

+ Manual dexterity to handle specimens and repair equipment

+ Ability to lift and transport equipment or specimens weighing up to 20 pounds

+ May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

+ PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

+ CV

+ Research statement

+ Letter of reference from current supervisor

+ All application materials should be submitted directly via email to Dr. Bruce D Trapp at [email protected] .

**Keywords:** Postdoc, Research, LRI, Multiple sclerosis, Surface-in gradients of brain pathology, Neurodegeneration, Microglia, Pathogens in CSF, DALT, Skull bone marrow, Spatial transcriptomics, Interlaminar astrocyte, Confocal microscopy

Pay Range

Minimum hourly: $0.01

Maximum hourly: $333,340.26

The pay range displayed on this job posting reflects the anticipated range for new hires. While the pay range is displayed as an hourly rate, Cleveland Clinic recruiters will clarify whether the compensation is hourly or salary. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set, and education. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision and retirement.

Cleveland Clinic Health System is pleased to be an equal employment employer: Women / Minorities / Veterans / Individuals with Disabilities