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Job Title: Downstream Processing TechnicianJob Description

The Downstream Processing Technician plays a pivotal role in supporting the manufacture of Commercial and Clinical Biologics. This position requires adherence to Current Good Manufacturing Practices (cGMPs) and involves a variety of functions related to Downstream purification and filtration using techniques such as HPLC. Responsibilities include propagation of mammalian cell culture, aseptic cell culture operations, execution of large-scale production bioreactors, and conducting large-scale filtration or centrifugation. The technician will also handle purification through large-scale chromatography.

Responsibilities

+ Review all area documents to ensure accuracy and compliance.

+ Manage the Warehouse Notification System (WNS).

+ Assist in the manufacture of controls and calibrators, completing batch records in compliance with cGMPs.

+ Perform in-process assays using equipment such as spectrophotometers, pH meters, and clinical analyzers.

+ Weigh, transfer, and mix chemicals as required for production processes.

+ Conduct product filtrations and ensure quality control.

+ Clean and steam steel tanks using Clean-In-Place (CIP) and Steam-In-Place (SIP) procedures.

+ Prepare glassware and steel tanks for sterilization using an autoclave, and operate the autoclave effectively.

+ Maintain lab equipment including pumps, pH meters, and flow meters to ensure operational efficiency.

+ Keep department leads or managers updated on all operational issues.

+ Monitor stocks of common lab supplies to avoid shortages.

+ Respond to emergency notifications promptly.

+ Perform other job duties as required to support the team.

+ Work flexible hours, including weekends, as needed.

Essential Skills

+ Proficiency in cleanroom operations and aseptic techniques.

+ Experience with laboratory procedures and chemistry.

+ Minimum of 6 months experience in a GMP-regulated environment.

+ Bachelor's Degree in Science, preferably with knowledge in aseptic techniques, chemistry, HPLC, and chromatography.

Additional Skills & Qualifications

+ BS Degree in STEM-related field required.

+ Minimum of 2 years of work experience in manufacturing, operation, production, lab setting, or related field.

+ Preferred experience in a cGMP environment with a 4-year STEM degree.

+ Knowledge of cGMP practices, aseptic techniques, or chemical concepts is preferred.

+ Subject Matter Expert on downstream processing steps is preferred.

Work Environment

The work environment consists of cleanroom and aseptic suites, requiring full gowning which includes bodysuits, gloves, hair and beard nets, face covers, and safety glasses. Day shifts run from 6:15 am to 6:45 pm and night shifts from 6:15 pm to 6:45 am, with rotating 12-hour shifts working 7 days out of a 2-week period. Employees must meet clean room gowning requirements, including wearing Tyvek, Nitrile, and/or Latex gloves, and be capable of lifting a minimum of 25 lbs independently. Standing for 80% of the shift is required.

Pay and Benefits

The pay range for this position is $27.00 - $28.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Saint Louis,MO.

Application Deadline

This position is anticipated to close on Aug 6, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email [email protected] (%[email protected]) for other accommodation options.