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Discover Your Career at Emory University

Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future. We welcome candidates who can contribute to the excellence of our academic community.

Description

We are seeking a highly motivatedpostdoctoral fellowto join our research programfocused on sickle cell disease and otherhematologicdisorders. The candidate will workwithin a multidisciplinary environment at the interface ofpediatric hematology, molecularbiology, and translational research.

POSITION OVERVIEW:

+ Title: Postdoctoral Fellow in the Department of Hematology and Oncology,EmoryUniversity School of Medicine

+ Location:Aflac Cancer and Blood Disorders Center,Health Sciences ResearchBuilding I, Atlanta, GA

+ Lab/PI: Dr.Francesca Vinchi’slab

+ Focus: Investigating heme/iron dyshomeostasis in hematologic disorders (with afocus on sickle cell disease) and its contribution to disease pathogenesis andpathophysiology using translational models and omics/single-cell technologies.

POSITION SUMMARY:

The position is responsible for research aimed at investigating mechanisms ofheme/iron-driven toxicities in sickle cell diseases. Under the guidance of the PI,Dr. Vinchi, the research fellow will study the impact of heme and iron overload onthe pathophysiology of sickle cell diseases as well as the pathogenesis of otherhuman hematological diseases. The candidate will perform cutting-edge researchthat integrates hematology and immunology with novel therapies using innovativetechnologiesandapproachesincludingclassicmolecular,cellular,andbiochemical techniques, as well asmodern imaging techniques, RNA sequencingand metabolomics at bulk and single cell levels, bioinformatics, and preclinical invitro and in vivo models.

RESEARCH FOCUS AND GOALS:

+ Understandingheme/iron-drivenmolecular mechanisms ofalteredhematopoiesis,immuneactivationandvasculardysfunctionandtheirimplicationsinthepathogenesis and pathophysiology of sickle cell disease and other hematologicdiseases.

+ Studyingheme/iron metabolism,hematopoiesis, andimmunology ininherited oracquired anemias.

+ Applyingcutting-edge methods, includingcell culture, mouse modeling and invivo/exvivo mouse experiments,flowcytometry,scRNA-seq, metabolomics,real-time PCR, western blotting,in vitro hematopoietic assays.

+ Modifyingheme/iron-relatedpathwaysthroughtherapeuticcompoundsincollaboration with pharmaceutical/industrypartners.

+ Contributingto translational science, helping to shape mechanistic biologicalinsights that feed intonew clinical trialsin the field of hematology.

RESPONSIBILITIES:

+ Work independently on a research project under the supervision of the Lab Head

+ Daily molecular bench work

+ Working with miceand performing in vivo experimentson a regular basis

+ Managing mousecolonies,including genotyping

+ Working with mammalian cell culture (primary and cell lines), including human bone marrow and peripheral blood cells.

+ Maintaininglab files related to the general laband research experiments.

+ Reportingresearch progress while maintaining up to date knowledge of literaturein relevant fields.

+ Summarizingexperimental data, assist in drafting figures, results and methods forpresentations, publications and grants.

JOB DESCRIPTION:

+ Helps design and conduct research within a specified field while receiving advanced training from a designated Principal Investigator to enhance professional skills and research independence needed for pursuit of a career.

+ The specific area of research in which the trainee is mentored is determined by the department and laboratory of the Postdoc.

+ Designs and evaluates experiments.

+ Develops new ideas that promote current research.

+ Prepares and publishes scientific manuscripts under the direction of the Principal Investigator.

+ May be responsible for operation of specific equipment.

+ May teach techniques to others, train, and supervise research staff.

+ Positions are temporary appointments as a research trainee.

+ The initial appointment is for one year, renewal expected if progress is satisfactory and funds are available.

+ Appointments cannot exceed five years.

MINIMUM QUALIFICATIONS:

+ A doctoral degree or equivalent (Ph.D., M.D., ScD., D.V.M., DDS etc) in an appropriate field.

+ Excellent scientific writing ability and strong oral communication skills.

+ The ability to work effectively and collegially with colleagues.

+ Additional qualifications as specified by the Principal Investigator.

PREFERRED QUALIFICATIONS:

+ PhD or MD/PhD in hematology, cell biology, molecular biology, or related field.

+ Prior experience withmouse models,basicmolecularbiologytechniques, andcell-based assays

+ Strong record of productivity andpeer-reviewed publications.

+ Excellent communication skills and ability to work in acollaborative researchenvironment.

+ Ability toperform experimentsindependentlyunder PI’s guidance,provide inputinto experimental design,identify problems in a timely manner, evaluate optionsand implement solutions.

OPPORTUNITIES:

+ Mentored training in a NIH-funded, high-impact research program.

+ Access touniqueresources at Emory School of Medicine,includingstate-of-the-art core facilities, clinical collaborators, andpartnering institutions like GeorgiaTech.

+ Participation in career development programs and academic training workshopsat Emory and Children’s Healthcare of Atlanta.

+ Opportunity to work onindustry-relevanttranslational projectswith real patientsamples and preclinical models.

+ Collaboration with oncologists,hematologist, and drug developers.

HOW TO APPLY:

Submityour applicationonline via Emory Careers, including:

+ Curriculum Vitae

+ Cover letteroutlining your research interests

+ Contact information for three referees

+ Inquiries can be sent directly to [email protected]

NOTE: Position tasks are required to be performed in-person at an Emory University location; working remote is not an option. Emory reserves the right to change this status with notice to employee.

Additional Details

Emory is an equal opportunity employer, and qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by state or federal law. Emory University does not discriminate in admissions, educational programs, or employment, including recruitment, hiring, promotions, transfers, discipline, terminations, wage and salary administration, benefits, and training. Students, faculty, and staff are assured of participation in university programs and in the use of facilities without such discrimination. Emory University complies with Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veteran's Readjustment Assistance Act, and applicable executive orders, federal and state regulations regarding nondiscrimination, equal opportunity, and affirmative action (for protected veterans and individuals with disabilities). Inquiries regarding this policy should be directed to the Emory University Department of Equity and Civil Rights Compliance, 201 Dowman Drive, Administration Building, Atlanta, GA 30322. Telephone: 404-727-9867 (V) | 404-712-2049 (TDD).

Emory University is committed to providing reasonable accommodations to qualified individuals with disabilities upon request. To request this document in an alternate format or to request a reasonable accommodation, please contact the Department of Accessibility Services at 404-727-9877 (V) | 404-712-2049 (TDD). Please note that one week's advance notice is preferred.

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**Job Number** _151249_

**Job Type** _Regular Full-Time_

**Division** _School Of Medicine_

**Department** _SOM: Peds: Sickle Cell_

**Campus Location (For Posting) : Location** _US-GA-Atlanta_

**_Location : Name_** _Emory Campus-Clifton Corridor_

**Remote Work Classification** _No Remote_

**Health and Safety Information** _Working in a laboratory, Working with animals_