• Research Scientist 1

    Massachusetts Institute of Technology (Cambridge, MA)


    Research Scientist 1

     

    + Job Number: 25172

    + Functional Area: Research - Scientific

    + Department: Center for Biomedical Innovation

    + School Area: Engineering

    + Pay Range Minimum: Not Available

    + Pay Range Maximum: Not Available

    + Employment Type: Full-Time

    + Employment Category: Exempt

    + Visa Sponsorship Available: Yes

    + Schedule: M-F, Standard Hours

    + Pay Grade: No Grade

     

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    Posting Description

    RESEARCH SCIENTIST 1, The Center for Biomedical Innovation CBI, to design and execute experiments to help develop new understandings and methods for testing small extracellular vesicles (sEV) for therapeutic delivery. Will be responsible for developing methods suitable for rapid bacterial and adventitious agent (AA) detection in sEV manufacturing based upon [1] rapid Mass Spectrometry detection of a metabolomic signature specific for bacterial contamination and [2] next-generation sequencing-based detection of sample contamination with AA genetic material. The performance of these methods will then be validated through spiking studies during continuous sEV manufacturing and ultimately integrate them into the process. The Research Scientist will support validation efforts by providing technical clarification or additional data as needed to assist those conducting spiking studies; perform next-generation sequencing (NGS) in complex biological matrices; and design and execute NGS workflows with attention to sample quality, data integrity, and context-specific challenges unique to complex biological systems.

    Job Requirements

    REQUIRED: Ph.D. and a minimum of two years of experience in Biochemical or Chemical Engineering, Biological Sciences, or a closely related field; experience with traditional molecular biology techniques such as PCR,ELISA, and Western blotting; ability to work both independently and as part of a team; a record of effectively prioritizing multiple responsibilities, troubleshooting technical issues, and establishing detailed technical protocols; and strong professional communication and documentation skills including internal communications, external publications, scientific presentations, and various forms of recordkeeping. PREFERRED: Highly motivated individuals with experience performing NGS, especially in a complex matrix; and experience in the growth of mammalian cells as well as experience with the development of rapidpoint of use of analytical tools.

     

    8/28/2025