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Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (https://jobs.mayoclinic.org/benefits/) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

+ Medical: Multiple plan options.

+ Dental: Delta Dental or reimbursement account for flexible coverage.

+ Vision: Affordable plan with national network.

+ Pre-Tax Savings: HSA and FSAs for eligible expenses.

+ Retirement: Competitive retirement package to secure your future.

Responsibilities

The laboratory of Dr. Irani is seeking a highly motivated Postdoctoral Research Fellow to join the Protein Engineering and Biochemistry in Autoimmune Neurology Group in Jacksonville, Florida. This position will support and expand ongoing research efforts in translational protein engineering towards curing and diagnosing autoimmune encephalitis, neuromyelitis optica, dementias and related neurological diseases. The successful candidate will continue and extend the research pipeline established by Dr. Stephan Steinke, focusing on the production and characterization of patient-derived autoantigen-specific monoclonal antibodies, autoantigen discovery and engineering, and their combined use towards novel diagnostic tools under GLP/GCP-compliant frameworks.

Responsibilities

• Process and manage clinical trial samples

• Design, produce, and validate neuronal antigen proteins ("baitbodies") for B-cell sorting and epitope mapping

• Produce, purify and modify IgG, IgA and IgM monoclonal antibodies in-house using mammalian expression systems

• Develop, implement, and maintain SOPs for antibody QC, documentation, and compliance

• Collaborate with cross-functional teams and mentor junior scientists or technicians

Dr. Irani's faculty page: https://www.mayo.edu/research/faculty/irani-sarosh-r-b-m-b-ch-d-phil/bio-20557862

A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Upon background check and CCATS Executive Committee approval, Research Fellow may have patient/research subject contact directly relating to and incidental to the original research program. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.

Qualifications

• Ph.D. in Biotechnology, Immunology, Molecular Biology, or related field

• Experience in antibody engineering, protein purification and biochemistry

• Understanding antibody sequence data (identification of V-genes and C-domains) and antibody data bases (e.g. VBASE, IMGT etc.)

• Antibody cloning experience (e.g. GoldenGate, Gateway, classic)

• Hands-on experience with mammalian cell culture, ELISA, SDS-PAGE, and affinity chromatography (e.g., ÄKTA)

• Methods to epitope map autoantibodies and determine their functionalities

• Familiarity with GLP, GMP and GCP standards

• Excellent communication and organizational skills

• Proactive, solution-oriented mindset with attention to scientific rigor and documentation

Preferred Qualifications

• Knowledge of CNS-targeted immuno-engineering and autoimmune disease models

• Prior work with protein production and immune epitope mapping

• Familiarity with regulatory documentation and clinical trial sample workflows

Exemption Status

Exempt

Compensation Detail

$64,079 - $74,963 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Varies

Weekend Schedule

Varies

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations)

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (https://www.eeoc.gov/poster) . Mayo Clinic participates in E-Verify (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter

Amy Hoffman

Equal opportunity

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.