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A Postdoctoral position is available in the Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. This position reports to Dr. Pavan Bachireddy in the Department of Hematopoietic Biology & Malignancy.

We are seeking a talented and highly motivated Postdoctoral Fellow interested in understanding the evolutionary dynamics of measurable residual disease (MRD) progression within the bone marrow microenvironment. Our lab uses unbiased, high-throughput technologies to decode the rules of interaction among diverse cell types in the tumor milieu that determine patient outcomes to cancer immunotherapy, primarily in hematologic malignancies (NEJM 2016; Cell 2018; Sci Transl Med 2020; Blood 2021; Cell Reports 2021; Cancer Cell 2023).

We are especially interested in Fellows with molecular biology expertise to interrogate subclonal evolution, using integrative analyses of jointly measured transcriptomic, proteomic and epigenomic measurements at single cell resolution. Furthermore, in vitro genome-editing and in vivo experiments will be critical approaches to validate and extend our findings.

The Postdoctoral Fellow will have access to the extensive research platforms at MD Anderson and the broader Texas Medical Center, including computation clusters, single-cell core facilities, epigenetics core facilities, flow cytometry facilities, drug screening cores, and animal colonies, among many others.

Dr. Bachireddy is also deeply committed to the career growth and success for each member of the laboratory. Such mentorship should be intentional, planned and tailored to each member of the group - thus the laboratory operates with a primary goal of fostering career goals and development for each individual.

All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.

*LEARNING OBJECTIVES*

The Postdoctoral Fellow will conduct experiments, perform data analysis and prepare manuscripts in addition to attending lab meetings, journal clubs, and research seminars. The Postdoctoral Fellow's primary research focus is on hematologic malignancies that determine patient outcomes to cancer immunotherapy. The Postdoctoral Fellow will train, learn and study design, data analysis and manuscript writing as well as learn to give articulate oral presentations in preparation for career progression.

The fellow will lead work focused on 1) interrogation of factors defining MRD; 2) evolutionary modeling of cancer-immune interactions over time and 3) identification of programs driving MRD progression across myeloid malignancies, using multiple cutting-edge technologies as well as standard cell culture and immunologic approaches. Because Dr. Bachireddy is also the Scientific Director of the ECLIPSE (Evolution of Cancer, Leukemia and Immunity Post Stem Cell transplant) platform, the fellow will have significant interaction and access to the vast immunogenomic and computational resources of the physically adjacent ECLIPSE platform.

We are looking for an enthusiastic, self-motivated, independent thinker with a tremendous work ethic. The position will require great planning and organizational skills. An ability to work well with others as part of a cohesive team, take initiative, and creatively problem solve are a must.

*ELIGIBILITY REQUIREMENTS*

Individuals with a PhD degree in immunology, molecular biology, genomics, genetics, or related fields. Experiences that are desirable (but not required) include: immunology (e.g. T cell assays), CRISPR, and/or next-gen sequencing (bulk or single cell genomics) within myeloid malignancies. Candidate should have the ability to prioritize and manage multiple projects. Proven track record of publications, excellent written and oral communication skills are required.

*POSITION INFORMATION*

MD Anderson offers full-time postdoc positions with a [salary ranging from $64,000 to $76,000](https://trainees.mdanderson.org/apply/mdaPostdoctoralFellowStipendFY24.pdf). depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent [benefits](https://www.utsystem.edu/offices/employee-benefits/insurance-0/eligibility), including medical, dental, [paid time off](https://www.mdanderson.org/about-md-anderson/employee-resources/leave.html), [retirement](https://www.utsystem.edu/offices/employee-benefits/ut-retirement-program/voluntary-retirement-programs), tuition benefits, educational opportunities, and individual and team recognition

Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements.

This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. [http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html](http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html)