"Alerted.org

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through Cleveland Clinic Research. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.

A postdoctoral fellow or research associate position is available immediately in the laboratory of Dr. Laura Nagy in the Department of Inflammation and Immunity at the Cleveland Clinic to study the role of the innate immune system, including toll-like receptor signal transduction and complement activation, in the progression of alcohol-associated liver disease (ALD) and tissue injury.

The research will focus on the effects of chronic ethanol on key signal transduction pathways in hepatocytes, hepatic macrophages and stellate cells with a goal towards understanding the mechanism of development of chronic inflammatory responses and hepatocyte injury in liver.

Projects related to regulation of cell death pathways, interferon signaling, complement in kidney injury and pathways of gut-liver or adipose-liver interactions are available. Approaches used in the lab range from molecular to translational, with an emphasis on bioinformatics.

Experience in at least one of the following areas is desired: cell biology, signal transduction, molecular biology, complement, liver or kidney physiology, bioinformatics or macrophage biology. Experience in experimental design and data analysis in cultured cells, animal models and large 'omics datasets is preferred. Strong written and oral communication skills are required.

Candidates should have a recent PhD in cell biology, immunology, biochemistry, or a related discipline and experience in signal transduction and cell biology.

**Principal Investigator:** Laura E. Nagy, PhD

**Cleveland Clinic Research Department:** Inflammation and Immunity

Lab Research Topics:

+ Liver disease

+ Cell death

+ Signal transduction

+ Macrophage biology

+ Complement

+ For more information about the lab's research, please visit: https://www.lerner.ccf.org/inflammation-immunity/nagy/ or contact Dr. Nagy at [email protected] .

Job Responsibilities:

+ Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation

+ Conduct independent research

+ Share data via written manuscripts and oral presentations

+ Collaborate with other lab and team members

Education:

+ PhD or MD/PhD required

+ MD with relevant laboratory experience may substitute for PhD

Languages:

+ English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

+ Previous experience in a research or academic setting. Graduate student experience meets this requirement.

+ Scientific writing experience

Additional Preferred Qualities:

+ Cell culture

+ Bioinformatics/statistics

+ Signal transduction

Physical Requirements:

+ Ability to perform work in a stationary position for extended periods

+ Ability to operate a computer and other office equipment

+ Ability to communicate and exchange accurate information

+ Ability to distinguish color

+ Manual dexterity to handle specimens and repair equipment

+ Ability to lift and transport equipment or specimens weighing up to 20 pounds

+ May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

+ PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

+ CV

+ Contact information for 3 references

+ All application materials should be submitted directly via email to Laura Nagy at [email protected] .

**Keywords:** Postdoc, Research, LRI, Postdoctoral fellow, Research associate, Liver disease, Acute kidney injury, Metabolic liver disease, Fibrosis

Pay Range

Minimum hourly: $0.01

Maximum hourly: $333,340.26

The pay range displayed on this job posting reflects the anticipated range for new hires. While the pay range is displayed as an hourly rate, Cleveland Clinic recruiters will clarify whether the compensation is hourly or salary. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set, and education. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision and retirement.

Cleveland Clinic Health System is pleased to be an equal employment employer: Women / Minorities / Veterans / Individuals with Disabilities