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A Research Fellow position is available in the laboratory of Dr. Keith Ligon in the fields of brain tumor biology and precision medicine and the Department of Pathology at the Dana-Farber Cancer Institute. Prior experience and desire to perform wet-lab research and cell biology focused research and molecular methods is required. The position will involve the multidisciplinary study of cancer cell biology and mechanisms of treatment resistance in adult and pediatric gliomas with a focus on the use and training in a cutting edge techniques such as spatial biology methods, patient-derived human models of cancer, CRISPR functional precision medicine, engineering of human cell models, AI/ML methods, human clinical trials, correlative tissue biomarker analysis, genomics studies. Skills or ability to apply computational approaches and implementation of bioinformatics methods is desired. Developing independence will be fostered, and opportunities for intellectual input will also be readily available. The Ligon lab environment is highly collaborative and there will be opportunities to interact with top-tier investigators and their teams in translational and basic science collaborations at the national and international level.

Fellows also have opportunity for joint appointments at the Broad Institute, Harvard Medical School, and Brigham and Women’s Hospital as projects require. Applicants will have excellent mentoring and training for academia and industry.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

+ Design, direction, and execution of research experiments to address problems in brain tumor biology and resistance to treatment

+ Pathology review and annotation of features from H&E and immunostaining methods

+ Analysis of patient derived models (PDX and organoids) and effects of treatments on these patient models

+ Informatics analysis and interpretation of results from clinical trial patient samples, and in vitro or in vivo assays (genomic sequencing, RNA sequencing)

+ Use of spatial biology methods (e.g. Xenium, GEOMx, CyCIF, HALO AI) to examine tissue responses in models and patient samples

+ Communication presentation of results at meetings and manuscript preparation

+ Ph.D. or equivalent is required

+ Knowledge of AI/ML Methods

+ Skills or ability to apply computational approaches and implementation of bioinformatics methods is desired.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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