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At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub** **Function:

Translational Discovery & Development Biomarkers

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

About Immunology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

An internal pre-identified candidate for consideration has been identified. However, all applications will be considered.

We are searching for the best talent for a Scientist, Translational Sciences (TS), Immunology Translational Sciences and Medicine (TSM) to be located in San Diego, CA.

Translational Sciences and Medicine (TSM) is an integrated group of scientists composed of a clinical Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies, and a Translational Sciences (TS) team which uses human based data and tissues to support the end-to-end portfolio. Together, the TSM group will provide the key learnings/insights on the next wave of novel therapies for patients. Organizationally, TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group. TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases.

TS has a broad remit stretching from support of discovery with human data to support target selection, through development of novel decision-making biomarkers for early phase clinical trials, target-centric indication sequencing and prioritization, and biomarker support of regulatory filings. The TS organization accomplishes these goals by integrating expertise in biomarker development, disease biology research and in the application of immunology and data science technologies to support drug discovery and development.

This position will reside within the ImmunoDermatology group in the Immunology Translational Sciences department and requires a highly motivated and skilled candidate to assist in the clinical progression of innovative therapies across diseases. The successful candidate will be responsible for conducting in vitro cellular assays and human biospecimen analysis to support immunology portfolio assets. The candidate will also conduct assay optimization and development, biomarker discovery and external collaboration biospecimen analysis to further Johnson & Johnson Innovative Medicine leadership in immunodermatology. The candidate will bring an enthusiastic discovery mindset to Translational Sciences.

The Scientist will be designing and conducting translational science research to support the Johnson & Johnson immunology portfolio. The selected candidate will conduct translational research to support clinical biomarker analysis, molecular and cellular profiling of therapeutic targets using primary human cells and in vitro cell based functional assays for mechanism of action studies. The person in this role will engage in the planning, execution, and interpretation of laboratory experiments. S/he will be conducting experiments with limited guidance and will be expected to collaborate with internal and external partners (CROs) on assay development and translational research. The candidate will also evaluate and optimize methods for novel platforms to enable multi-omics analysis of patient derived samples. Further, the candidate will operate in a highly collaborative environment and deliver high quality support for key stakeholders such as the Dermatology Disease Area Stronghold (DAS), and the Translational Science and Medicine team.

Responsibilities are as follows:

+ Manage, process, and analyze clinical study samples, including minimally invasive skin tissue samples (e.g., tape stripping, skin scraping, microneedling)

+ Isolate and culture immune cells from skin and blood

+ Conduct _ex vivo_ experiments and cell-based assays using primary human tissue and immune cells

+ Perform protein and RNA extraction from minimally invasive skin samples or skin tissues

+ Perform novel assay development and qualification

+ Utilize molecular biology techniques including RNA/protein extraction, qPCR, immunoassays, bulk RNAseq, and Olink-HT to generate proteomic and transcriptomic data

+ Perform and analyze immunohistochemistry (IHC) and immunofluorescence (IF) staining

+ Apply HALO-AI or similar platforms for image analysis

+ Operate and troubleshoot TECAN automation systems for sample processing

+ Execute research activities under limited supervision and provide critical analysis and interpretation of data

+ Rigorous and timely data generation for clinical trial samples

+ Communicate experimental findings through oral presentations and written reports; maintain accurate and detailed experimental records in accordance with company guidelines

+ Contribute to conference posters and peer-reviewed publications

+ Collaborate closely with team members and adhere to J&J EHS&S safety standards to maintain a safe and productive work environment

Qualifications:

+ Bachelor’s degree in a scientific discipline with 3–5 years of relevant experience, or Master’s degree with at least 1 year of experience in biology, immunology, or related field

+ Strong organizational skills and attention to detail; ability to manage multiple tasks and troubleshoot effectively

+ Hands-on experience with mammalian cell culture is required

+ Proficiency in molecular biology techniques including DNA/RNA/protein extraction, qPCR, RNAseq, and immunoassays

+ Experience with histology, IHC/IF staining and analysis, spatial transcriptomics, and scRNAseq is preferred

+ Experience with TECAN automation and HALO-AI image analysis platforms is highly desirable

+ Experience handling skin samples, including minimally invasive sampling techniques (e.g., tape stripping, skin scraping, microneedling), is strongly preferred

+ Background in inflammation or immunology research is strongly preferred

+ Proactive mindset with a strong desire to learn, troubleshoot, and grow professionally

The anticipated base pay range for this position is: $88,000 - $141,450

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

• Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

• This position is eligible to participate in the Company’s long-term incentive program.

• Employees are eligible for the following time off benefits:

• Vacation – up to 120 hours per calendar year

• Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year

• Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year

• Additional information can be found through the link below. https://www.careers.jnj.com/employee-benefits

The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

\#LI-Onsite

The anticipated base pay range for this position is :

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