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Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

Job description - Senior Associate Scientist

The successful candidate will join the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early-stage therapeutics in Oncology TRC. The position will utilize in-vivo models to profile novel biologics like T cell engagers.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in Discovery Oncology, protein engineering/antibody development, DMPK and translational group. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.

Qualifications

+ A B.S. with 2-7 years relevant industry or comparable academic experience and a clearly demonstrated skill set in in vivo oncology or cancer cell signaling is required.

+ Demonstrated competency in independently using in vivo mouse tumor models to perform PK/PD and efficacy studies in conjunction with blood/tissue collection is required.

+ Experience with subcutaneous syngeneic and xenograft tumor models is required; experience with GEMMs and PDx models is a plus.

+ Competency in murine dosing, i.e. PO, IP, IV, SC, is required; intra-tumor and IM is preferred.

+ Proficiency in cell culture, passaging and harvesting is required. Experience with preparing adherent and suspension mammalian cells for subcutaneous and intravenous implantation preferred.

+ Experience in independently processing blood samples, harvesting and disaggregating tumors, spleen and preparing samples for FACS analysis

+ Independently set up FACS multichannel panels and routinely profile tumors, blood and lymphoid organs by Flow cytometric analysis. Expected to analyze FACS data and present the analysis to the team.

+ Demonstrated experience executing ex vivo assays to investigate target engagement, mechanism of action and biomarkers by qPCR, ELISA (MSD), WB. Familiar with cytokine profiling studies and analysis by MSD & Luminex methods.

+ Experience with orthotopic or chemically induced mouse models or rodent surgical experience is a plus.

+ Proficiency in utilizing software such as GraphPad Prism™, electronic notebooks, Microsoft office etc. for data analysis and figure generation is required.

+ Excellent organizational skills and a detail-oriented approach to the execution of experiments and record keeping is a requirement.

+ Strong interpersonal skills with the ability to interact effectively with peers and management is required.

Responsibilities include

+ Independently conduct mouse in vivo pharmacology experiments, including but not limited to model development, tumor implantation, dosing via IV, IP, SC, I-TUMOR, IM and PO routes, tumor measurements, health monitoring, tissue sampling by fine needle biopsy and core needle biopsy, peritoneal lavage, blood draws by retro-orbital, tail vessel micro-sampling, cardiac puncture and tissue/tumor collection at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses.

+ Independently conduct in vivo efficacy and PK/PD studies and experiments supporting the development of new pharmacology models.

+ Contribute to the utilization of ELISAs (MSD), qPCR, or WB to monitor biomarkers and cytokines in harvested tissues & blood samples. Isolate PBMC and primary T cells from Leukopaks and functionally characterize them using cell-based assays.

+ Contribute to the utilization of multi-color flow cytometry to profile the immune infiltrate in harvested mouse tissues.

+ Accurately maintain proper scientific documentation associated with pharmacology studies in an electronic lab notebook.

+ Effectively communicate and present summaries of research results to team members or to a multidisciplinary team of researchers.

+ Rotating weekends, holidays and off-hour on-site responsibilities to support in life studies, when applicable, will be expected of this position.

+ This position is located in Cambridge, MA.

+ \#LI-ONSITE

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

Cambridge Crossing: $105,040 - $127,287

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected] . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

**Company:** Bristol-Myers Squibb

**Req Number:** R1595910

**Updated:** 2025-10-15 03:59:50.034 UTC

**Location:** Cambridge Crossing-MA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.