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The laboratory of Dr. Humam Kadara studies ecological mechanisms in early lung cancer development and response to immune-based treatment (e.g., Sinjab et al, Cancer Discovery, 2021; Hao et al, Cancer Discovery, 2022; Han et al, Nature, 2024).

We seek a talented and highly motivated computational postdoctoral fellow with a strong background in bioinformatics and passion in exploring the heterogeneity and evolution of tumor cells and the tumor microenvironment (TME) following immunotherapy using state-of-the-art single-cell and spatial profiling approaches. The primary research focus of the candidate postdoc will be to employ innovative bioinformatics approaches to dissect in both human-relevant models of lung cancer as well as unique cohorts of human lung tissues the tumor "ecosystem" and profile in-depth phenotypic and functional heterogeneity, lineage plasticity and evolutionary dynamics of tumor and TME cells as well as cell-cell interactions in order to better understand lung cancer development, progression and therapeutic response. The postdoc candidate will work in close collaboration with the Cascone Laboratory at MD Anderson.

*LEARNING OBJECTIVES*

Learn and master skills for in-depth profiling of single cell sequencing and spatial transcriptomics data. Learn and master skills for integrative analysis of high-dimensional bulk and single-cell multi-omics data. Gain rich knowledge in cancer biology, cancer genomics and immunogenomics, and cancer-specific bioinformatics. Develop skills in study design, data interpretation, presentation, and manuscript writing. Develop skills in networking, career planning, teaching, grant writing, and other professional development skills that can help the candidate fellow's career trajectory.

All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations

*ELIGIBILITY REQUIREMENTS*

Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply.

A strong computational background, proficiency in R and at least one additional scripting language (e.g., Python) and knowledge in biostatistics are required. Experience working with single cell sequencing data and high-performance computing environment is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. Proven track record of publications, excellent spoken and written communication skills are required. This appointment is not part of a clinical training program; individuals holding an M.D. degree or equivalent are not permitted to engage in patient care activity.

*ADDITIONAL APPLICATION INFORMATION*

Please check the following link for more information on the Kadara lab:

https://www.mdanderson.org/research/departments-labs-institutes/labs/kadara-laboratory.html

*POSITION INFORMATION*

MD Anderson offers full-time postdoc positions with a [salary ranging from $64,000 to $76,000](https://trainees.mdanderson.org/apply/mdaPostdoctoralFellowStipendFY24.pdf). depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent [benefits](https://www.utsystem.edu/offices/employee-benefits/insurance-0/eligibility), including medical, dental, [paid time off](https://www.mdanderson.org/about-md-anderson/employee-resources/leave.html), [retirement](https://www.utsystem.edu/offices/employee-benefits/ut-retirement-program/voluntary-retirement-programs), tuition benefits, educational opportunities, and individual and team recognition

Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements.

This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. [http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html](http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html)