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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Biologist - Cell Biologist** **– Neurodegeneration

Overview

Eli Lilly has a proud record of drug discovery and development for Alzheimer’s Disease with a highly competitive portfolio of industry leading assets. We are now seeking highly motivated scientists to join the Neurodegeneration team to facilitate its mission of discovering novel medicines for the treatment of Amyotrophic Lateral Sclerosis, Alzheimer’s Disease, Parkinson’s disease, and other related neurodegenerative conditions.

Position Summary

We are seeking a Cell Biologist to join the ND Boston group within the Neurodegeneration Division. This role focuses on advancing research in neurodegenerative diseases, with a strong emphasis on Parkinson’s disease. The ideal candidate will bring expertise in cellular and molecular biology, combined with hands-on experience in advanced laboratory techniques.

You will develop and optimize cellular models of synucleinopathies using both cell lines and iPSC-derived neurons, enabling physiologically relevant assays for target validation, compound profiling, and the discovery of novel therapeutics. This is an exciting opportunity to contribute to Lilly’s mission of delivering innovative treatments for patients while building a career in industry.

Key Responsibilities

+ Design, implement, and refine cellular models of neurological diseases and cellular physiology (e.g., protein aggregation, seed amplification, lysosomal and mitochondrial pathways).

+ Culture and differentiate patient-derived stem cells into neurons to establish drug discovery platforms.

+ Perform genetic manipulations, including overexpression and knockdown of disease-relevant targets.

+ Conduct phenotypic characterization of cells to uncover disease mechanisms and pathways.

+ Develop and execute high-content imaging assays, including image analysis and biochemical/functional measurements.

+ Collaborate effectively across multidisciplinary teams to drive project milestones.

+ Communicate results clearly through reports, presentations, and team meetings.

+ Maintain accurate electronic lab notebooks in compliance with Lilly quality standards.

+ Ensure a safe, organized, and efficient laboratory environment.

Basic Requirements:

+ Masters Degree in neuroscience, cell biology, stem cell biology, biochemistry or a related scientific discipline with 1+ years of work experience, or a Bachelors degree in scientific discipline with 2+ years of work experience.

Required Skills & Experience

+ Strong background in Parkinson’s disease and/or neurodegenerative biology.

+ Expertise in iPSC culture, characterization, banking, and neuronal differentiation.

+ Proficiency in molecular biology techniques (e.g., gel electrophoresis, Western blotting, RT-PCR, ELISA).

+ Experience with genetic manipulation (viral vectors, knockdown strategies, CRISPR) and physiologically relevant models.

+ Solid understanding of experimental design and statistical analysis.

+ Knowledge of laboratory safety standards.

Preferred Qualifications

+ Familiarity with cellular models of protein aggregate propagation and related assays (e.g., ThioflavinT, protein seeding, luminescence and FRET-based assays).

+ Ability to troubleshoot and interpret complex cell-based and biochemical assays.

+ Demonstrated independence in experimental design, data analysis, and documentation.

+ Strong organizational skills, attention to detail, and time management.

+ Excellent communication skills and ability to work collaboratively in a team-oriented environment.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$71,250 - $187,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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