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42702BR

Extended Job Title:

TTU Research Associate - Dr. Murali Vijayan's Lab

Position Description:

Performs specialized work in the planning, conducting and/or supervising of original research. Responsible for participating in, planning, scheduling and/or supervising research projects and the interpretation of the results for publication. Work is performed under general supervision with evaluation based on accomplishment of assigned objectives and overall effectiveness of project. May supervise research and student assistants. Adherence to robust safety practices and compliance with all applicable health and safety regulations are responsibilities of all employees.

Requisition ID:

42702BR

Travel Required:

None

Major/Essential Functions:

Molecular Biology Experiments

1. Perform RNA isolation, quality assessment, and quantification from human and rodent tissues or cell lines.

2. Carry out quantitative PCR (qPCR), RT-PCR, and small RNA library preparation for sequencing.

3. Analyze microRNA expression profiles using targeted assays or high-throughput technologies.

miRNA Data Analysis and Bioinformatics

1. Analyze miRNA expression datasets (e.g., from RNA-seq, NanoString, or qPCR arrays).

2. Use bioinformatics tools to identify differentially expressed miRNAs across ischemic stroke and Alzheimer’s disease samples.

3. Perform pathway and target prediction analyses using tools such as Ingenuity Pathway Analysis, TargetScan, or miRDB.

Cellular and In Vitro Functional Assays

1. Conduct gain- and loss-of-function studies using miRNA mimics/inhibitors in relevant cell models (e.g., neuronal, glial, or iPSC-derived cells).

2. Assess cellular outcomes such as viability, mitochondrial function, apoptosis, or synaptic integrity in response to miRNA manipulation.

Collaboration and Documentation

1. Work closely with PI, postdocs, and other lab members to design experiments and troubleshoot protocols.

2. Maintain accurate and detailed laboratory records, protocols, and data files.

3. Contribute to manuscript preparation, figure generation, and presentations for scientific meetings.

4. Maintain lab equipment and ensure availability of reagents related to RNA work.

5. Train junior lab members or students on miRNA techniques and lab protocols as needed.

Grant Funded?:

Yes

Pay Basis:

Monthly

Work Location:

Lubbock

Preferred Qualifications:

1. Master’s or Ph.D. degree in Neuroscience, Molecular Biology, Biomedical Sciences, or a related field.Prior research experience in microRNA biology, neurodegenerative diseases (especially Alzheimer’s disease), or ischemic stroke.

2. Publication record in peer-reviewed scientific journals relevant to neuroscience, molecular biology, or RNA research.

3. Experience working in a collaborative, multi-investigator research environment.

Preferred Knowledge, Skills, and Abilities

+ Hands-on experience with RNA-seq or small RNA sequencing workflows, including library preparation and QC.

+ Bioinformatics skills for miRNA data analysis, such as using R, Python, or specialized tools (e.g., DESeq2, TargetScan, miRDB, Ingenuity Pathway Analysis).

+ Previous research experience in Alzheimer’s disease and/or ischemic stroke models (in vitro or in vivo).

+ Demonstrated experience contributing to peer-reviewed publications or scientific presentations.

+ Ability to adapt quickly to new techniques and protocols in a fast-paced research environment.

+ Experience coordinating with multi-institutional or interdisciplinary research teams.

Department:

Nutritional Sciences

Required Attachments:

Cover Letter, Professional/Personal References, Research Statement, Resume / CV

Job Type:

Full Time

Shift:

Day

Required Qualifications:

Master's degree or specialized academic training beyond the Bachelor's level in a particular field of science or engineering equivalent to a Master's degree. One year research experience. Knowledge of modern research practices, the methods, resources, and standards thereof.

Does this position work in a research laboratory?:

Yes

Safety Information:

Adherence to robust safety practices and compliance with all applicable health and safety regulations are responsibilities of all TTU employees.

Pay Statement:

Compensation is commensurate upon the qualifications of the individual selected and budgetary guidelines of the hiring department, as well as the institutional pay plan.

EEO Statement:

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, disability, genetic information or status as a protected veteran.

About the University:

Established in 1923, Texas Tech University is a Carnegie R1 (very high research activity) Doctoral/Research-Extensive, Hispanic Serving, and state-assisted institution. Located on a beautiful 1,850-acre campus in Lubbock, a city in West Texas with a growing metropolitan-area population of over 300,000, the university enrolls over 40,000 students with 33,000 undergraduate and 7,000 graduate students. As the primary research institution in the western two-thirds of the state, Texas Tech University is home to 10 colleges, the Schools of Law and Veterinary Medicine, and the Graduate School. The flagship of the Texas Tech University System, Texas Tech is dedicated to student success by preparing learners to be ethical leaders for a diverse and globally competitive workforce. It is committed to enhancing the cultural and economic development of the state, nation, and world.

About Lubbock:Referred to as the “Hub City” because it serves as the educational, cultural, economic, and health care hub of the South Plains region, Lubbock boasts a diverse population and a strong connection to community, history, and land. With a mild climate, highly rated public schools, and a low cost of living, Lubbock is a family-friendly community that is ranked as one of the best places to live in Texas. Lubbock is home to a celebrated and ever-evolving music scene, a vibrant arts community, and is within driving distance of Dallas, Austin, Santa Fe, and other major metropolitan cities. Lubbock’s Convention & Visitors Bureau provides a comprehensive overview of the Lubbock community and its resources, programs, events, and histories.

Job Family:

Research

Job Sub Family:

Researchers & Scientists

Knowledge, Skills, and Abilities:

1. Strong understanding of microRNA biology and its relevance to neurodegenerative diseases such as Alzheimer’s disease and ischemic stroke.

2. Hands-on experience with RNA isolation and qPCR, particularly for microRNA expression analysis.

3. Proficiency in culturing and maintaining mammalian cells, including neuronal or glial cell models.

4. Ability to analyze and interpret gene expression data, including differential expression and pathway analysis.

5. Excellent organizational and record-keeping skills to ensure data integrity and reproducibility.

6. Ability to work independently, troubleshoot experiments, and manage time effectively.

7. Strong communication skills, both written and verbal, for data presentation and collaboration.

8. Willingness and ability to train and assist junior lab members, including students and interns.

Annualized Pay Range:

$44,500 - $57,900 - $71,200