"Alerted.org

Lead, Cancer Biology Research and Therapeutics, Disease Mechanism Research

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Purpose and Scope:

The Disease Mechanism Research team is seeking an exceptional scientific leader versed in state-of-the art methods in oncology research. The ideal candidate should demonstrate deep understanding of cancer biology and provide scientific direction for pre-clinical research in Astellas’ Cancer Biology team. The successful candidate will lead a diverse team of scientists to build a deeper understanding of cancer biology in focused cancer indications and advance the Astellas oncology pipeline.

Essential Job Responsibilities:

+ Expert knowledge of tumor biology, including cancer cell intrinsic and extrinsic mechanisms leading to disease progression and maintenance

+ Provide extensive expertise in cancer biology, including model and assay development to support preclinical drug development

+ Establish key in vitro and ex vivo immuno-oncology assays and models suitable for therapeutic evaluation and mechanistic investigation across the Astellas portfolio

+ Mentor and support a team of junior researchers to address mechanisms of action and resistance to cancer therapies

+ Contribute to program development through broad expertise in oncogenic signaling pathways

+ Manage multiple projects simultaneously and act as a project lead to effectively collaborate cross-functionally with colleagues across the Astellas organization

+ Effectively communicate with team members to efficiently conduct experiments, articulate experimental details and results with other members of the Astellas research organization, and present research findings and recommendations to senior leadership

Qualifications Required:

+ PhD and post-doctoral training in cancer biology, cancer immunotherapy or a closely related fields with a minimum of 7+ years postdoctoral experience in an academic or industry setting

+ Experience and strong interest in cancer therapy and/or immuno-oncology research

+ Demonstrated expertise in solid tumor biology and tumor model development

+ Proven ability to drive innovative research strategies and deliver results

+ Recognized leadership in mentoring talent, establishing best practices, and ensuring experimental rigor

+ Excellent verbal, written, and interpersonal communication skills are essential

+ Strong work ethic with a dedicated mindset of proactively identifying and productively filling gaps

Preferred:

+ Understanding of novel modalities in cancer therapeutics including but not limited to targeted protein degradation, ADC and bispecific T cell engager platforms

+ Knowledge of methodologies employed in tumor metabolism research

+ Experience in multicellular in vitro models

Working Environment:

+ This position is based in South San Francisco (West Coast Innovation Center) and will require on-site work.

**Salary Range** **:** $140,000 - 200,000 (NOTE: Final salary could be more or less, based on experience)

Benefits:

+ Medical, Dental and Vision Insurance

+ Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

+ 401(k) match and annual company contribution

+ Company paid life insurance

+ Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

+ Long Term Incentive Plan for eligible positions

+ Referral bonus program

\#LI-TR1

Category Cancer Biology

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans