"Alerted.org

Why Patients Need you

At Pfizer, our purpose is to deliver breakthroughs that transform patients' lives. Central to this mission is our Research and Development team, which strives to convert advanced science and cutting-edge technologies into impactful therapies and vaccines. Whether you are engaged in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, your role is crucial. You will leverage innovative design and process development capabilities to expedite the delivery of top-tier medicines to patients globally.

How You Will Achieve it

We are seeking a highly motivated and innovative Ph. D. graduate to join our Mass Spectrometry Technologies team in Drug Safety R&D. The role involves developing and implementing a mass spectrometry-based spatial proteomics platform to support oncology investigations. The successful candidate will leverage cutting-edge mass spectrometry and spatial proteomics technologies-including laser capture microdissection (LCM) and data-independent acquisition mass spectrometry (DIA-MS)-to elucidate the heterogeneity of tumor microenvironments, therapeutic distribution, and mechanisms of toxicity in solid tumors. This role offers valuable experience in drug development and drug safety, working collaboratively with multidisciplinary teams.

Key Responsibilities

+ Design and optimize spatial proteomics protocols combining LCM and DIA-MS, leveraging state-of-the-art technologies (Leica LMD, Thermo Astral Zoom MS) to generate high-quality datasets from low-input tissue material.

+ Apply AI-based image analysis to guide tissue selection and enhance workflow precision and throughput.

+ Map protein localization within tumor microenvironments and evaluate tumor penetration and distribution of therapeutics to gain insights into therapeutic responses, disease and tox mechanisms.

+ Participate in all phases of mass spectrometry lab operations, including sample preparation, instrument maintenance, and troubleshooting.

+ Work in a state-of-the-art mass spectrometry laboratory, engaging with cross-functional teams across Drug Safety R&D and Pfizer.

+ Maintain rigorous electronic records and data storage.

+ Publish findings in peer-reviewed journals and present at both internal and external forums.

Must Have:

+ Ph.D. in Analytical Sciences, Biochemistry, Molecular Biology, or a closely related field (0-2 years postdoctoral experience).

+ No more than 2 years of post-degree experience.

+ Experience in MS-based proteomics, including sample preparation workflows, high-resolution MS, nanoLC systems, associated instrument and analytical software packages.

+ Experience in laser capture microdissection and/or other techniques for spatial analysis (IHC, immunofluorescence).

+ Strong written and oral communication skills.

+ Demonstrated scientific curiosity, organizational skills, and attention to detail.

+ Successful record of scientific accomplishments evidenced by scientific publications and/or presentations with at least one first-author publication in a peer-reviewed journal

+ Willingness to make a minimum 2-year commitment

Preferred Qualifications:

+ Understanding of oncology, toxicology, or drug development.

Other Job Details:

+ Work Location On premise

+ **Must have work authorization in the US.**

The annual base salary for this position ranges from $62,700.00 to $104,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [email protected]. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

Research and Development