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At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

**Location:** Foster City, CA

**Term:** 3-Year Fixed Term

About the Role

Join a pioneering team at the forefront of computational and structural biology, driving innovation to transform therapeutic discovery. We are seeking an exceptional **Postdoctoral Scientist** to lead research focused on predicting and optimizing protein–protein interactions using cutting-edge approaches that combine physics-based modeling, machine learning, and experimental validation, advancing the design of next-generation proteins and antibodies.

This position is a joint appointment between Research Data Sciences and Protein Therapeutics, providing a unique opportunity for cross-functional collaboration and exposure to diverse expertise.

As a Postdoctoral Scientist, you will have the freedom to design and lead an independent research project, publish in high-impact journals, and work alongside world-class scientists across computational and experimental disciplines. Your contributions will directly shape the future of biologics and antibody therapeutics.

What** **You’ll** **Do

+ Develop advanced computational workflows for protein modeling, structural analysis, and molecular simulations.

+ Apply machine learning and physics-based approaches to predict and optimize protein-protein interactions.

+ Analyze large-scale biological datasets to uncover insights that guide experimental design.

+ Validate computational predictions and generate critical training datasets in the lab.

+ Optimizeautomated cloud-based pipelines for large-scale predictions and data processing.

+ Publish and present your findings at top-tier conferences and journals.

Basic Qualifications

+ Ph.D. in Computational Biology, Bioinformatics, Structural Biology, Biophysics, or related fields.

+ At least one first-author publication in a peer-reviewed journal.

+ Strong Python programming skills with extensive experience using scientific libraries (e.g., NumPy, SciPy, pandas) and deep learning frameworks including PyTorch and TensorFlow.

+ Expertise in protein modeling tools (AlphaFold, RFDiffusion, Rosetta, PyMOL, etc)

+ Hands-on experience with molecular dynamics packages (AMBER, GROMACS, etc) is a plus.

+ Familiarity with antibody structure and protein engineering principles.

+ Proficiency in Linux environments and deploying workflows on HPC clusters.

+ Excellent problem-solving and communication skills.

Preferred Qualifications** **(one** **or more** **of the following)

+ Experience with graph neural networks, diffusion models, or generative frameworks for antibody design and optimization.

+ Knowledge of enhanced sampling techniques (Metadynamics, Umbrella sampling).

+ Understanding binding thermodynamics and free energy calculations.

+ Experience and/or familiaritywithapproaches for affinity validation and screening in the lab (e.g. high throughput recombinant protein production, ELISA, SPR/BLI, flow cytometry, display technologies, NGS) - training provided as needed.

The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

For jobs in the United States:

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact [email protected] for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' (https://www.eeoc.gov/employers/eeo-law-poster) poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT (http://www.dol.gov/whd/regs/compliance/posters/eppac.pdf)

YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law.

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please apply via the Internal Career Opportunities portal in Workday.

Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.