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Job Title: Scientist IIIJob Description

The Scientist III, Biologics Downstream Process Development will independently conduct laboratory experiments with limited supervision to develop purification processes and support technology transfer and manufacturing of biological drug candidates. The incumbent will utilize their technical expertise in downstream/purification process development of biologics to advance CMC development and manufacturing for pre-IND and in-clinic therapeutic proteins. A strong technical focus is critical to ensure the speed, cost effectiveness, and technical quality of our CMC activities.

Responsibilities

+ Develop and execute laboratory studies in downstream process development to support unit operation scale-up and technology transfers.

+ Undertake production campaigns from Lab to Pilot Scale.

+ Collaborate with internal and external partners in upstream process development, analytical development, and formulation development groups.

+ Maintain complete and accurate records of laboratory work in conformance with standard operating procedures (SOPs) and training.

+ Provide detailed reviews of peer-generated data as well as that generated from contracted service providers.

+ Maintain the inventory of laboratory consumables and clean glassware.

+ Coordinate vendor service calls for repair and maintenance of laboratory instruments, perform routine maintenance of laboratory instrumentation, and maintain complete and accurate records of instrument service and repairs.

+ Establish, maintain, and lead internal downstream process development and scale-up lab capabilities in CMC Biologics.

Essential Skills

+ Bachelor’s degree in chemistry, biochemistry, biochemical engineering, chemical engineering or related field with a minimum of three years of relevant drug discovery/development experience.

+ Master’s degree in chemistry, biochemistry, biochemical engineering, chemical engineering or related field with a minimum of one year of relevant drug discovery/development experience.

+ Hands-on experience in recombinant protein purification and downstream process development.

+ Experience with Fast Protein Liquid Chromatography (FPLC) systems for chromatography-based purification development.

+ Experience developing scalable chromatography purification unit operations.

+ Experience developing scalable viral filtration and TFF unit operations.

+ Working knowledge of CMC upstream process development, analytical development, formulation development, bioconjugation process development, technology transfer, and GMP quality requirements.

Additional Skills & Qualifications

+ Familiarity with harvest and clarification unit operations.

+ Ability to run basic analytical purity assays and in-process impurity clearance assays independently.

+ Demonstrated capability to work independently on complex technical problems and effectively in cross-functional teams.

Work Environment

The work environment is primarily in laboratories, with exposure to hazardous materials and extreme cold. The position requires a regular shift from 8 AM to 5 PM and does not allow for remote work. Limited travel is required.

Job Type & Location

This is a Contract to Hire position based out of Alameda, CA.

Pay and Benefits

The pay range for this position is $58.00 - $63.10/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Alameda,CA.

Application Deadline

This position is anticipated to close on Nov 25, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email [email protected] (%[email protected]) for other accommodation options.