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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organizational Overview:

The Bioproduct Research and Development (BR&D) organization strives to deliver innovative medicines to patients through the development and commercialization of monoclonal antibodies, novel therapeutic proteins, peptides, bioconjugates, cell therapies, gene therapies, and other genetic medicines etc. This organization is a multidisciplinary group that works collaboratively with our discovery, manufacturing and quality, business units.

Position Summary:

The current position focuses on small-molecule drug-linker synthetic chemistry. The current opportunity is within the Bioproduct Research and Development (BR&D) organization, which is a multidisciplinary organization focused on the development and commercialization of biologic therapeutics such as monoclonal antibodies and bioconjugates. Due to a strategic commitment to the growth of novel modalities such as Antibody-Drug Conjugates (ADCs) and an exciting pipeline of investigational medicines within the Lilly portfolio, we are seeking outstanding candidates to work at this exciting small molecule – biologics interface. The successful candidate will interface closely with the biologics development in BR&D and with the Synthetic Molecule Design and Development organization (SMDD) at Lilly.

Position** **Responsibilities:

To meet the needs of Lilly’s expanding and diverse portfolio of ADCs, our team is tasked with growing the chemistry infrastructure to conduct the synthesis and process development of highly-potent and/or cytotoxic ADC drug-linkers. We will utilize a combination of in-house and external development, while building the capabilities to develop and transfer processes to internal and external manufacturing partners. A successful applicant should bring a skillset and knowledge to help grow our team’s capabilities, research facilities, and infrastructure. Lilly has an expanding and diverse portfolio of ADCs that require thorough drug-linker process development.

+ Synthesize complex payloads and drug-linkers for preclinical tox studies, and collaborate across internal Lilly networksto implement and deliver material and information

+ Possess fluent knowledge in synthetic organicchemistry methods, technologies, and techniquesand apply these skills to design and develop robust synthetic manufacturing processesfor use in clinical manufacturing campaigns.

+ Possess solid understandinginunit operation design, process modeling, process equipmentselection, and scale-up methodologies.

+ Work closely with early phase Discovery and Toxicologygroups to supportnew and emerging assets in the portfoliovia synthetic material supply

+ Provide technical leadership in the scale-up and demonstration of new chemical processes in development scale equipment; collaborate with internal and external manufacturing partners to develop robust chemical processes that are readily amenable to efficient drug substance manufacturing.

+ Design experimental laboratory plans in support of route and process design, definition, optimization, and technology transferobjectives.

+ Support generating data to be used in regulatory filings. Possess ability to address key CMC regulatory questions that enable clinical studies.

+ Engage the external chemistrycommunitythrough presentationsandpublications.

+ Collaborate with other Lilly chemists, analytical chemists, bioconjugation scientists, engineers, CMC project management, Lilly manufacturing partners, and regulatory scientists to develop and commercialize ADCs.

+ Oversee phaseappropriate developmentactivities such as routeselection, process definition, and process characterization.

+ Partnerwith external development and manufacturing organizations to quicklydeliver ondevelopment and commercialization needs (data and material).

+ Authortechnical reportsand CMC related documentsincludingsections in regulatory submission documents (e.g., IND, IMPD, BLA).

+ Help drive internal facilities growth to supporthighly-potentand/or cytotoxic material handlingthrough assisting in laboratory design and planning.

Basic Requirements:

+ Ph.Din synthetic organic chemistryor relevant scientific disciplinewith 0-2 years of industryexperiencein the field of synthetic organic chemistry OR MS degree with 5+ years of relevant synthetic chemistry experience in an industrysetting.

Additional Skills/Preferences:

+ Experience working in a high-potentlaboratory environment, with experience handlingand manipulatinghigh-potent and/or cytotoxic compoundsis a plus.

+ Experience working with Antibody-Drug Conjugates (ADCs)is a plus.

+ An active scientific curiosity and interestincomplementary disciplines within the pharmaceutical industry.

+ Familiarity with preparative scale chromatographic purification of small molecules.

• **Additional Information:**

+ Potential exposure to chemicals, allergens, and loud noises.

+ Travel: 0–20%

+ Full time salaried position.

+ Locatedin Indianapolis, Indiana, Lilly Technology Center – North.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$126,000 - $204,600

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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