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Job Description

Salary: $74,692

Department: Oncological Sciences

Physical work location:

Icahn School of Medicine at Mount Sinai

1468 Madison Ave

Annenberg 24-60

New York, NY 10029

Name PI: Elvin Wagenblast, PhD [email protected]

Web link to Lab:

https://profiles.mountsinai.org/elvin-wagenblast

https://wagenblastlab.com/

Administrative Contact: Evelyn Markov, [email protected]

Qualifications

Educational and other Requirements for the position:

+ PhD in cancer biology, hematology, immunology, or a related biomedical discipline

+ Demonstrated experience in molecular biology and murine models

+ Strong communication skills and ability to work independently and collaboratively in a team

Experience Required:

+ Prior experience with CRISPR-based genome editing and/or xenograft models

+ Familiarity with hematopoietic stem cell biology and immune phenotyping preferred

+ Experience analyzing high-dimensional datasets (e.g., scRNA-seq) is an asset but not required

Goals/Outcomes of the Research Project:

+ Define the molecular and cellular mechanisms by which mutant clonal hematopoiesis alters the bone marrow niche

+ Identify specific cytokines and cell types responsible for metastasis promotion

+ Evaluate targeted interventions in preclinical models

+ Generate high-impact publications and lay the foundation for future host-targeted metastasis prevention strategies

Responsibilities

Details of Research Project:

The Wagenblast Lab investigates how somatic evolution in the hematopoietic system influences cancer progression. The postdoctoral fellow will focus on a project exploring how TET2-mutant clonal hematopoiesis remodels the bone marrow into a metastasis-permissive niche for solid tumors, particularly breast cancer. Using humanized xenograft models, the lab studies the inflammatory and stromal alterations induced by clonal hematopoiesis and evaluates therapeutic strategies targeting cytokine signaling. The fellow will leverage cutting-edge tools including CRISPR/Cas9 genome editing, single-cell and spatial transcriptomics, and preclinical mouse modeling to dissect how mutant immune cells orchestrate metastatic progression.

Technical Duties: (include any protocols)

+ Generate genome-edited hematopoietic stem/progenitor cells (HSPCs) using CRISPR/Cas9

+ Perform xenotransplantation of human HSPCs into immunodeficient mice

+ Analyze bone marrow and tumor samples via flow cytometry, immunohistochemistry, and histology

+ Conduct bioluminescence imaging to monitor metastasis progression

+ Assist in spatial transcriptomics using 10x Visium HD and single-cell RNA sequencing workflows

+ Maintain primary cell cultures, perform viral transduction, and cytokine assays

+ Participate in manuscript preparation and presentation of findings

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.