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At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Specific Responsibilities:

The primary responsibility of this **Biologics DMPK Senior Scientist** position is to serve as an expert in pharmacokinetic (PK) and PK/PD modeling of biologics, providing strategic and scientific leadership on large molecule discovery and development project teams. The role emphasizes the application of advanced quantitative approaches, including mechanistic and empirical modeling, to characterize and predict the absorption, distribution, metabolism, and excretion (ADME) properties of protein therapeutics. Additionally, responsibilities include designing and interpreting in vitro and in vivo studies, integrating data into mathematical models, and generating simulations to support dose selection and clinical translation. This role offers opportunities to serve as a project representative and departmental modeling expert, while also contributing to business development initiatives and external collaborations.

Essential Duties and Job Responsibilities:

+ Provide advanced PK and PK/PD modelingexpertiseon project teams across discovery and development stages, guiding the design and interpretation of nonclinical PK, toxicology, and pharmacology studies.

+ Lead quantitative DMPK strategyfor biologics programs, collaborating with interdisciplinary teams to integrate modeling approaches into decision-making; communicate modeling insights and align strategies with scientists, collaborators, and management.

+ Design, implement, andvalidatecomplex PK/PD and mechanistic modelsto address translational questions, support dose selection, and predict first-in-human exposures.

+ Develop and refine modeling workflowsfor nonclinical study design, including simulation-based approaches to optimize study parameters and interpret outcomes.

+ Prepare study protocols and coordinate execution of nonclinical studies which may involve multiple functional areas and CROs.

+ Work closely with project teams,linemanagementand CROs toassurehigh quality andtimelydelivery of written PK reports and regulatory documents (IND, IMPD, IB, BLA) for regulatory submissions.

+ Participate in business development and licensing evaluations.

Basic Qualifications:

+ Bachelor’s Degree and8 Years’ Experience

OR

+ Masters’ Degree and6 Years’ Experience

OR

+ PhD/ PharmDand2 Years’ Experience

OR

+ MD

Preferred Qualifications:

+ Ph.D. with 3+ years of post-graduate industry experiencein pharmacokinetics, drug metabolism, pharmaceutics, or a related life science field, with a primary focus on quantitative modeling for large molecule/biologics PK characterization across discovery and development.

+ Strongfoundationin pharmacokinetics and pharmacodynamics principles, withdemonstratedability to translate these concepts into mathematical models.

+ Extensiveexperience in mechanistic PK/PD and multi-compartmental modeling, includingproficiencywith software platforms such asPhoenix/WinNonlin, MATLAB/SimBiology, R, or equivalent modeling tools.

+ Provenability to design, implement, and interpret complex modeling workflows,determinenext steps based on quantitative insights, and effectively communicate results to project teams and senior management.

+ Demonstratedintellectual curiosity and commitment to staying currentwith advances in biologics DMPK and modeling methodologies, supported bya track recordof external visibility through publications, presentations, and/or professional organization involvement.

The salary range for this position is: $169,320.00 - $219,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

For jobs in the United States:

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact [email protected] for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' (https://www.eeoc.gov/employers/eeo-law-poster) poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT (http://www.dol.gov/whd/regs/compliance/posters/eppac.pdf)

YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law.

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please apply via the Internal Career Opportunities portal in Workday.

Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.