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At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub** **Function:

Pharmacokinetics & Pharmacometrics

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

**Purpose:** The Senior Scientist will join our Global Translational ADME group, an area within the Translational Pharmacokinetics (PK)/Pharmacodynamics (PD) & Investigative Toxicology (TPPIT) department. Our global translational ADME team is committed to providing project teams with mechanistic insights and integrating data to understand the correlations between in vitro and in vivo ADME properties, as well as the interplay between PK, toxicokinetics and PD responses.

The Translational ADME team in La Jolla is seeking a highly motivated Senior Scientist to support J&J’s discovery and early development programs. In this role, you will design and complete in vitro screening and mechanistic ADME studies to enable comprehensive PK/PD and safety characterization of small molecules and other modalities such as molecular glues and proteolysis targeting chimeras (PROTACs). Additionally, you will establish workflows to support the ADME characterization of drug candidates by establishing next generation complex in vitro models. This position will require hands-on lab work, while also offering personal growth opportunities through training, mentoring, and R&D-wide connectivity. You will author reports and scientific publications and present data to the scientific community both internally and externally.

We are searching for the best talent for a Senior Scientist, Preclinical Safety & Translational Sciences - Translational PK to be located in La Jolla, CA.

You will be responsible for:

+ Independently designing, performing, and managing various in vitro screening and mechanistic ADME studies to address specific DMPK questions in drug discovery.

+ Developing analytical methods using mass spectrometry (LC-MS/MS and HRMS) to separate and detect small molecules and other modalities.

+ Analyzing and interpreting experimental data.

+ Preparing and delivering scientific presentations and reports to communicate research results within and outside the TPPIT department.

+ Maintaining current knowledge of relevant scientific literature and evaluating implications for internal projects.

+ Maintaining laboratory equipment as well as clear, detailed, and up-to-date experimental records.

Qualifications / Requirements:

Education:

+ A minimum of a Bachelor's degree in Biomedical Science, Pharmaceutical Science or a relevant Life Sciences field is required. An advanced degree (Masters, PhD) is highly preferred.

Experience and Skills:

+ Bachelor’s degree: A minimum of 6 years of relevant industry experience is required; Master’s degree: A minimum of 4 years of relevant industry experience is required; PhD degree: A minimum of 2 years of relevant experience, including PhD, postdoc, industry experience is required.

+ Postdoctoral research or experience with complex in vitro assays is preferred.

+ Experience with designing, performing and interpreting a broad range of in vitro ADME assays such as metabolism stability, DDI, CYP inhibition, CYP induction, plasma protein or tissue binding assays is required.

+ Proficiency in using and troubleshooting a LC-MS/MS (Sciex instrumentation is a plus), cell culture and laboratory automation is preferred.

+ High degree of scientific curiosity and creativity to tackle complex investigational hypotheses is required.

+ Highly motivated and able to work in a fast-paced environment with a desire to learn and tackle new challenges is required.

+ Exceptional organizational skills are required.

+ Capability to manage multiple divergent research lines while maintaining oversight of project timelines and status is required.

+ Strong interpersonal, verbal and written communication skills necessary for facilitating efficient interactions with both internal teams and external collaborators is required.

The anticipated base pay range for this position is $109,000 to $174,800.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.

+ Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

+ Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

+ Employees are eligible for the following time off benefits:

+ Vacation – up to 120 hours per calendar year

+ Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year

+ Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year

+ Additional information can be found through the link below. https://www.careers.jnj.com/employee-benefits

The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

This job posting is anticipated to close on 11/27/2025. The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

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Required Skills:

Preferred Skills:

Analytical Reasoning, Clinical Data Management, Clinical Pharmacology, Clinical Trials Operations, Coaching, Critical Thinking, Drug Discovery Development, Empowering People, Pharmacokinetic Modeling, Pharmacokinetics, Pharmacology, Pharmacometrics, Program Management, Report Writing, Scientific Research, Technologically Savvy

The anticipated base pay range for this position is :

The anticipated base pay range for this position is $109,000 to $174,800.

Additional Description for Pay Transparency: