• Downstream Processing Technician

    Actalent (St. Louis, MO)


    Job Title: Downstream Processing TechnicianJob Description

     

    The Downstream Processing Technician will support the manufacture of Commercial and Clinical Biologics, adhering to Current Good Manufacturing Practices (cGMPs). The role involves a variety of functions related to Downstream purification and filtration/HPLC, including propagation of mammalian cell culture and execution of large-scale bioreactor production.

    Responsibilities

    + Review all area documents.

    + Responsible for the WNS.

    + Assist in the manufacture of controls and calibrators, and complete batch records following cGMPs.

    + Perform in-process assays using equipment such as spectrophotometers, pH meters, and clinical analyzers.

    + Weigh, transfer, and mix chemicals as required.

    + Perform product filtrations.

    + Clean and steam steel tanks (CIP/SIP).

    + Prepare glassware and steel tanks for sterilization in autoclave and operate autoclave.

    + Maintain lab equipment, including pumps, pH meters, and flow meters.

    + Keep department lead or manager updated on all issues.

    + Monitor stocks of common lab supplies.

    + Perform other job duties as required.

    + Respond to emergency notifications.

    + Work flexible hours and on weekends.

    Essential Skills

    + Minimum of 2 years of work experience in manufacturing, operation, production, lab setting, or related field.

    + BS Degree in STEM related field.

    + Knowledge of cGMP practices, aseptic techniques, or chemical concepts.

    + Subject Matter Expertise in downstream processing steps.

    Additional Skills & Qualifications

    + 6 months of experience in a GMP regulated environment and aseptic technique preferred.

    + Bachelor's Degree in Science with focus on aseptic technique, chemistry, HPLC, and chromatography.

    + Experience in a cGMP environment with a 4-year STEM degree preferred.

    Work Environment

    This position requires working in CLEAN ROOM/Aseptic suites during night shifts from 6:15pm to 6:45am. The schedule involves rotating 12-hour shifts, working 7 days out of a 2-week period. Employees must be willing to wear full gowning attire, including a bodysuit, gloves, hair & beard nets, face covers, and safety glasses. The environment prohibits makeup, jewelry, nail polish, cologne, scented lotions, or hair care products. Employees must meet clean room gowning requirements and be able to lift a minimum of 25 lbs independently and stand for 80% of the shift.

     

    Job Type & Location

     

    This is a Contract to Hire position based out of Saint Louis, MO.

    Pay and Benefits

    The pay range for this position is $32.20 - $32.20/hr.

     

    Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

     

    • Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)

     

    Workplace Type

     

    This is a fully onsite position in Saint Louis,MO.

     

    Application Deadline

     

    This position is anticipated to close on Dec 17, 2025.

    About Actalent

    Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

     

    The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

     

    If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email [email protected] (%[email protected]) for other accommodation options.