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Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans (https://jobs.mayoclinic.org/benefits/) – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

+ Medical: Multiple plan options.

+ Dental: Delta Dental or reimbursement account for flexible coverage.

+ Vision: Affordable plan with national network.

+ Pre-Tax Savings: HSA and FSAs for eligible expenses.

+ Retirement: Competitive retirement package to secure your future.

Responsibilities

**The Haak and Tschumperlin labs at Mayo Clinic are seeking Postdoctoral Research Fellows to join our research groups for advanced training related to lung fibrosis and repair.** Fellows will pursue NIH R01 funded basic and translational studies focused on fibroblast biology in the context of lung injury, inflammation, fibrosis and resolution. Our groups integrate mechanistic biology, chemical biology, and translational research to uncover how fibroblast subpopulations contribute to tissue pathology and to identify novel therapeutic strategies.

Research Focus for Project 1:

+ The molecular and functional roles of senescent fibroblasts in pulmonary fibrosis

+ Crosstalk between senescent/inflammatory fibroblasts and alveolar epithelial cells

+ Mechanisms linking aging, tissue repair, and fibroblast dysfunction

+ Discovery, characterization, and validation of small-molecule modulators using in vitro, ex vivo, and in vivo models

Research Focus for Project 2:

+ Define candidate transcriptional and epigenetic regulators of human fibroblast subpopulations in health and disease

+ Create advanced cell culture models to study fibroblast identity and plasticity as well as interactions with other relevant lung cell populations

+ Develop nano-delivery strategies to modulate fibroblast functions in vivo

Key Responsibilities:

+ Design and execute in vitro and in vivo experiments related to fibroblast and lung biology

+ Perform and interpret molecular, cellular, and biochemical assays

+ Work with primary human and mouse fibroblasts, alveolar epithelial cells, co-culture models, organoids, and precision-cut lung slices, and in vivo rodent models of lung fibrosis.

+ Collaborate with medicinal chemists and drug discovery scientists to evaluate compound efficacy

+ Lead manuscripts, present at conferences, and contribute to grant progress reports

+ Assist in mentoring graduate students

What We Offer:

+ A collaborative environment with broad expertise in lung biology, fibrosis, and drug-discovery

+ Opportunity to work at the intersection of fibrosis, cell and molecular biology, and therapeutic development

+ Access to state-of-the-art core facilities and screening platforms

+ Professional development support for career advancement

+ A robust training environment including potential eligibility for T32 support through our Translational Training in Respiratory Disease and Repair program

Qualifications

+ PhD or MD/PhD, in cell biology, molecular biology, pharmacology, biochemistry, bioengineering or a related field

+ Strong background in lung biology, fibrosis, cellular senescence, or fibroblast biology.

+ Demonstrated ability to independently design and perform experiments

+ Strong publication record

+ Excellent communication and teamwork skills

Preferred Skills:

+ Fibroblast–epithelial co-culture or organoid systems

+ Senolytics/senotherapeutics

+ Single-cell or bulk transcriptomics

+ Fibrosis models (bleomycin, etc.)

+ Mechanobiology or ECM remodeling

+ High-content imaging or phenotypic screening

Exemption Status

Exempt

Compensation Detail

$64,079 - $74,963 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. (https://jobs.mayoclinic.org/alllocations)

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law" (https://www.eeoc.gov/poster) . Mayo Clinic participates in E-Verify (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter

Kara Schott

Equal opportunity

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.