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A Postdoctoral Fellow position is available in the Department of Hematopoietic Biology & Malignancy at The University of Texas MD Anderson Cancer Center (MDACC) in Houston, TX. The fellow will work under the mentorship of Dr. Palaniraja Thandapani.

The Thandapani Lab studies tRNA expression and epitranscriptomic regulation of gene expression in both normal and malignant hematopoiesis. We recently identified altered tRNA biogenesis as a marker of tumor-specific amino acid demand in T-cell acute lymphoblastic leukemia (T-ALL) (Nature, 2021). These findings highlight how tRNA deregulation can uncover novel, targetable metabolic and translational vulnerabilities in cancer.

To advance this work, the lab leverages MDACC's extensive resources in primary human samples, patient-derived xenografts, and state-of-the-art genomic platforms. We apply next-generation and Nanopore sequencing to profile tRNA expression and epitranscriptomic changes across leukemia subtypes and normal hematopoietic compartments. These datasets are integrated with functional CRISPR screens, mechanistic approaches, and innovative therapeutic strategies (e.g., dietary modulation, RNA therapeutics, synthetic lethality) to define how tRNA dysregulation drives malignancy and to develop new therapeutic avenues for hematologic cancers.

This position places strong emphasis on individualized mentoring, setting clear goals and timelines to support successful transition to academic or industry careers based on the fellow's interests. The lab offers direct, hands-on mentorship from a young PI while also providing access to guidance from senior faculty in the department and across the Division of Cancer Medicine. MD Anderson is part of the vibrant UT medical and scientific community located in the highly affordable and diverse Houston metropolis.

All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.

*LEARNING OBJECTIVES*

The Postdoctoral Fellow will:

• Design and conduct experiments, analyze data, and prepare manuscripts.

• Participate in lab meetings, journal clubs, and research seminars.

• Lead research focused on understanding how dysregulation of tRNA biogenesis contributes to hematologic malignancies.

• Receive training in experimental design, data analysis, scientific writing, and oral presentation.

• Build the skills necessary for independent career progression in academia or industry.

*ELIGIBILITY REQUIREMENTS*

Individuals with a PhD degree in RNA biology, Genetics, Hematology, Chemistry or related fields. Candidate should have strong background in molecular biology, RNA biology, genomics, genetics, or related fields.

Preferred: prior experience studying hematopoiesis/ leukemia biology, mouse genetics and CRISPR screening. Proven track record of publications, excellent written and oral communication skills are required.

*ADDITIONAL APPLICATION INFORMATION*

For more information, visit the Thandapani lab webpage at https://www.mdanderson.org/research/departments-labs-institutes/labs/thandapani-laboratory.html

*POSITION INFORMATION*

MD Anderson offers full-time postdoc positions with a [salary ranging from $64,000 to $76,000](https://trainees.mdanderson.org/apply/mdaPostdoctoralFellowStipendFY24.pdf). depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent [benefits](https://www.utsystem.edu/offices/employee-benefits/insurance-0/eligibility), including medical, dental, [paid time off](https://www.mdanderson.org/about-md-anderson/employee-resources/leave.html), [retirement](https://www.utsystem.edu/offices/employee-benefits/ut-retirement-program/voluntary-retirement-programs), tuition benefits, educational opportunities, and individual and team recognition

Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements.

This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. [http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html](http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html)