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**Job Title:** Principal Scientist, Muscle and Neuromuscular Research

**Location:** Cambridge, MA

About the Job

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

We are seeking a highly motivated **Principal Scientist** to drive the expansion of our **muscle and neuromuscular research pipeline** through both internal discovery and external innovation. The successful candidate will possess deep expertise in **muscle biology** , ranging from normal muscle physiology to genetic cardiac, skeletal, and neuromuscular diseases

This individual will contribute by proposing new ideas and driving the advancement of pipeline programs. The candidate is expected to collaborate with academic and industry partners to **identify novel targets, disease mechanisms, and therapeutic approaches** . In parallel, they will **build and maintain relationships with key opinion leaders** to access disease models, patient samples, and translational resources that **accelerate biomarker discovery and de-risk later-stage research programs** .

The position offers the opportunity to work in a **highly collaborative environment** and to **mentor or manage a team of junior scientists** .

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities:

+ Initiate and lead pipeline programs in a modality agnostic manner (biologics, oligonucleotides, small molecules, genomic medicines), including hands on work in the lab

+ Landscape novel mechanisms and target discovery in the external space and balance with internal efforts to drive strategic direction and decisions within neuromuscular pipeline

+ Engage and strengthen KoL network to set up collaborations for early and late-stage research bringing in colleagues across research as needed

+ Work closely with and across project teams to advance rare muscle programs through early engagement with Translational Medicine Unit to build/strengthen biomarker strategies

+ Maintain close relationship with counterparts in Clinical, Medical, and Business Development organizations to support life cycle management as well as expansion of neuromuscular pipeline

+ Contribute to strategic initiatives, prepare high quality presentations and communications for senior leadership and contribute to publications and regulatory filings as needed

About You

Basic Qualifications:

+ Earned Ph.D. or equivalent advanced degree in molecular biology, cellular biology, or related discipline PLUS at least 5 years research experience in biopharmaceutical or academic setting

+ Experience in muscle biology and neuromuscular research

+ Experience in translational research and drug development

+ Track record of significant contribution to research projects and scientific publications

Preferred Qualifications:

+ Program leadership experience in the industry setting

+ Strong understanding of emerging science, leading therapeutic approaches and competitive landscapes for neuromuscular disorders

+ Experience with broad range of cell-based and animal models of muscle/neuromuscular disorders and cardiomyopthathies and relevant functional readouts

+ Experience with computational biology and implementing a broad range of ‘omics approaches, including subsequent data mining/analysis

+ Experience managing studies at CROs

+ Familiarity with wide range of therapeutic modalities including biologics, small molecules, oligonucleotides, and/or genomic medicines

+ The candidate is expected to have a strong network of research and clinician colleagues to leverage for collaboration and insight

+ Experience drafting regulatory documents to support IND or CTA applications with agencies like the FDA and EMA

Skills and competencies:

+ Ability to weigh and integrate inputs and opinions from broad range of stakeholders with diverse backgrounds

+ Ability to capture and distill complex data, concepts, and information into clear, well-articulated messages to guide and drive decision-making

+ Ability to multi-task and adapt to rapidly changing priorities and deadlines

+ Excellent critical thinking, analytical, and problem-solving skills

+ Excellent written and oral communication skills, with the ability to communicate effectively in a multi-disciplinary teams as well as to senior leadership

+ Strong interpersonal skills, with the ability to build excellent working relationships

Why Choose Us?

+ Bring the miracles of science to life alongside a supportive, future-focused team.

+ Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

+ Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

+ Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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Pursue** **_progress_** **, discover** **_extraordinary_

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) !

_US and Puerto Rico Residents Only_

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

_North America Applicants Only_

The salary range for this position is:

$122,250.00 - $176,583.33

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK (https://benefits.sanofiusallwell.com/fleet/public/index/ba511bf8-5c32-4828-9861-ab985fffab90/?cid=sanofi) .

Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/)

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo)

As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live.

All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)