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Job Description:

The RNome Core is a facility core within the National Institute of General Medical Sciences (NIGMS) COBRE: Center for the RNA Biology in Health and Disease created to provide an integrative suite of RNA biology services and advice to PIs in Rhode Island who are studying RNA while also training the next generation of RNA biologists through courses/workshops.

The RNome Facility Core Director, will be instrumental in establishing this core to provide long-read sequencing for identifying new RNA species and mapping RNA modifications both globally and at single-molecule level in sequence context. The RNome Facility Core Director will also add RNA biology functionality to integrate diverse existing cores allowing them to provide new RNA-related services as follows: 1) Identifying RBP occupancy and binding specificity with methods such as RNA immunoprecipitation followed by proteomics for RNA binding protein identification conducted by the Proteomics core, 2) RNA visualization with methods such as RNA FISH probe generation followed by imaging at the Imaging core, 3) RNA secondary structure analysis with methods such as FISH 4) RNA functional genomics with methods such as massively parallel reporter assays (MPRAs) followed by sequencing at the Genomics core, 5) experimental design for RNA biophysical and structural analysis in the Structural Biology core, and 6) facilitating data transfer to the Computational Biology Core.

Additionally, the RNome Facility Core Director will run a series of summer courses and workshops on RNA biology which will draw participants nationally and locally.

This is a fixed term position with a current end date of 08/30/2030 which may be extended based upon available funding.

Job Qualifications

Education and Experience:

+ Required: PhD degree in genetics, genomics or molecular biology or related field plus 5-7 years relative experience.

+ PhD graduate research experience in genomics and performing long read sequencing on RNA and DNA, ideally including mapping of RNA modifications.

+ Relevant coursework and advanced knowledge of laboratory approaches and techniques in RNA biology

+ Strong computational biology skills

+ Prior experience mentoring younger researchers as will supervise a technician

+ Experience operating Oxford Nanopore sequencer desired

Job Competencies:

+ Flexible availability to maintain and monitor 24/7 operation of Oxford Nanopore sequencer using remote access tools and in person if necessary and fixing problems as they arrive even outside of standard work hours.

+ Excellent written and communication skills.

+ Ability to be observant and self-motivated.

+ Ability to think critically and problem-solve.

+ Ability to work independently.

+ Ability to communicate clearly and professionally with core facility users.

+ Ability to complete accurate records and follow detailed instructions.

CRIMINAL BACKGROUND AND EDUCATION CHECK REQUIRED.

Benefits of Working at Brown:

Information on the Benefits of Working at Brown can be found here (https://www.brown.edu/a-z/benefits-working-brown) .

Recruiting Start Date:

2025-12-11

Job Posting Title:

RNome Facility Core Director

Department:

Department of Molecular Biology, Cell Biology and Biochemistry

Grade:

Grade 12

Worker Type:

Employee

Worker Sub-Type:

Fixed Term (Fixed Term)

Time Type:

Full time

Scheduled Weekly Hours:

37.5

Position Work Location:

Onsite

Submission Guidelines:

Please note that in order to be considered an applicant for any staff position at Brown University you must submit an application form for each position for which you believe you are qualified. Applications are not kept on file for future positions. Please include a cover letter and resume with each position application.

This position is not eligible for visa sponsorship.

Still Have Questions?

If you have any questions you may contact [email protected].

Brown is an E-Verify Employer.

EEO Statement:

Brown University provides equal opportunity and prohibits discrimination, harassment and retaliation based upon a person’s race, color, religion, sex, age, national or ethnic origin, disability, veteran status, sexual orientation, gender identity, gender expression, or any other characteristic protected under applicable law, in the administration of its policies, programs, and activities. The University recognizes and rewards individuals on the basis of qualifications and performance. The University maintains certain affirmative action programs in compliance with applicable law.