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The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech.

The Opportunity

We are seeking a highly motivated postdoctoral fellow to join the laboratory of Dr. Daniel Kirchhofer in the Department of Biological Chemistry at Genentech. This position offers an exciting opportunity to use state-of-the-art peptide display technologies - including phage and mRNA display of macrocyclic and cystine-knot peptide libraries - to discover peptides that modulate the function of therapeutically relevant protein targets. A major focus will be on members of the type II transmembrane serine protease family, cell-surface enzymes implicated in disease processes such as viral entry. In parallel, you will engineer disulfide-constrained peptide libraries designed to engage challenging, flat protein–protein interfaces, using a newly developed scaffold with a unique surface topology, and will leverage machine-learning-assisted methods for peptide sequence optimization. To elucidate mechanisms of peptide activity, the successful candidate will apply a broad range of biochemical, biophysical, structural, and cellular methods.

The ideal applicant is an independent, creative scientist who thrives in a collaborative, team-oriented environment. The position offers extensive opportunities to interact with the vibrant Genentech postdoctoral community as well as scientists across multiple departments.

Who You Are:

A Ph.D. in biochemistry, biophysics, structural biology or related discipline and a proven record of productivity in their graduate career as demonstrated by first-author publications.

Preferred Qualifications:

+ Strong experience in molecular biology

+ Expertise in engineering, expressing and purifying proteins

+ Experience with directed evolution (yeast, phage, mRNA display, etc.) is preferred

+ Experience in peptide chemistry is a plus

+ Proficiency in surface plasmon resonance or biolayer interferometry

+ Proficient in structural biology (crystallography and or cryo-EM) is a plus

+ Experience with tissue culture, cell-based assays

+ Strong analytical, collaborative, communication and organizational skills

For information about the Kirchhofer Lab at Genentech, please go to:

https://www.gene.com/scientists/our-scientists/daniel-kirchhofer

Postdoc Program

Elevate your research career to new heights with Genentech’s Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions.

The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader.

The Genentech Postdoc Program (http://careers.gene.com/us/en/students-postdocs) provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to Genentech Postdoctoral Program and unlock your full potential!

The expected salary range for this position based on the primary location of California is $100,000 to $106,500 . Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below.

Benefits (https://roche.ehr.com/default.ashx?CLASSNAME=splash)

Relocation benefits are available for this job posting.

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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (https://docs.google.com/forms/d/e/1FAIpQLSdZWlsbfQOvFVIQgHE\_iDzWUTlhZvj6FytIzjS7xq6IGh1H5g/viewform) .