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Scientist I, Antibody Engineering

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Astellas is announcing a **Scientist I, Antibody Engineering** opportunity at the Xyphos affiliate at the Astellas West Coast Innovation and Research Center in South San Francisco, CA.

Purpose:

We are seeking a talented Scientist to join our Antibody Engineering team in South San Francisco. This role will contribute to the design, molecular biology, purification and characterization of next-generation biologics, with a focus on innovative platform technology development for oncology programs.

Essential Job Responsibilities:

+ Lead antibody and protein production by performing purification of mAbs, bi-/multi-specific antibodies, and Fc fusion proteins at various scales using CHO and 293 cell lines

+ Perform QC and characterize recombinant antibodies and proteins from both internal and external sources; summarize results and present to project teams

+ Act as a technical lead for maintaining priority work and troubleshooting production issues

+ Plan and coordinate internal and external production activities and communicate with key stakeholders regularly

Qualifications

Required:

+ PhD with 0-2 years, MS with 4+ years, or BS with 6+ years of related experience in protein sciences team

+ Extensive experience in purification of mAbs, bi-/multi-specific antibodies, and Fc-fusion proteins using AKTA FPLC by protein A/G, IMAC, HIC, IEX, SEC chromatography methods

+ Experience in protein characterization techniques, such as analytical SEC, HIC, cIEF, CE-SDS/SDS-PAGE, DSF, and endotoxin testing

+ Demonstrated ability to conceive and design experiments, develop and optimize protocols/assays, and interpret experimental results

+ Demonstrated ability to work independently with minimal supervision and ability to effectively collaborate with other teams; collegiality is a critical attribute

+ Diligence and meticulous attention to detail in experimentation and ELN record keeping

+ Strong work ethic, good team player, willingness to fill gaps, demonstrated flexibility/adaptability to meet critical research related timelines

+ Collaborative mindset to work with global team members

Preferred:

+ Proficiencies in molecular biology techniques, including DNA construct design, PCR, DNA purification and molecular cloning

+ Prior experience in SPR/BLI and/or mass spectrometry

+ Knowledge of conditional activation: e.g. masking technologies, tumor-specific activation or payload delivery

Working Environment:

+ This position is based in the Astellas West Coast Innovation and Research Center and will require on-site work in a laboratory setting with R&D teams.

**Salary Range:** $91,000-$143,000 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience, and organizational equity considerations).

Benefits:

+ Medical, Dental and Vision Insurance

+ Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

+ 401(k) match and annual company contribution

+ Company paid life insurance

+ Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

+ Long Term Incentive Plan for eligible positions

+ Company-paid fleet vehicle for eligible positions

+ Referral bonus program

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Category Biologics Engineering

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans