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Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through Cleveland Clinic Research. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years. Compensation follows the NIH NRSA Postdoctoral Salary Scale based on total years of postdoctoral experience.

As a new PI, I'm looking for postdocs that are creative thinkers who can learn to run independent projects. The goal for the lab is to better understand the metabolic differences that drug treatments induce in therapy-resistant adult and pediatric gliomas. We are looking at investigating immune and microenvironment changes/dependencies in adult and pediatric gliomas in regard to redox stress. Prior knowledge of brain models is necessary (neuroscience or gliomas), as well as a basic background in immunology. Ability to understand and pick up chemistry would also be a plus.

**Principal Investigator:** Deanna Tiek, PhD

**Cleveland Clinic Research Department:** Center for Immunotherapy and ImmunoOncology/ Cancer Sciences

Lab Research Topics:

+ Drug resistant glioblastoma

+ Cancer metabolism

+ Immunology

+ For more information about the lab's research, please visit https://www.lerner.ccf.org/immunotherapy/tiek/ or contact Dr. Tiek at [email protected] .

Job Responsibilities:

+ Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation

+ Intracranial tumor injections; blood draws

+ Wet lab duties: cell culture, WB, IP, IF

+ Seahorse assays

+ Flow panel analysis with immune cell isolation

Education:

+ PhD or MD/PhD required

+ MD with relevant laboratory experience may substitute for PhD

Languages:

+ English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Certifications:

+ NA

Complexity of Work:

+ NA

Work Experience:

+ Previous experience in a research or academic setting. Graduate student experience meets this requirement.

+ Scientific writing experience

Physical Requirements:

+ Ability to perform work in a stationary position for extended periods

+ Ability to operate a computer and other office equipment

+ Ability to communicate and exchange accurate information

+ Ability to distinguish color

+ Manual dexterity to handle specimens and repair equipment

+ Ability to lift and transport equipment or specimens weighing up to 20 pounds

+ May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

+ PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

+ CV

+ References list

+ All application materials should be submitted directly via email to Deanna Tiek at [email protected] .

**Keywords:** Postdoc, Research, LRI, Glioblastoma, Metabolism, Cysteine/redox stress, Immunology

Pay Range

Minimum Annual Salary: $31,200.00

Maximum Annual Salary: $312,000.00

The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set and education. The pay range displayed does not include any applicable pay practices (e.g., shift differentials, overtime, etc.). The pay range does not include the value of Cleveland Clinic's benefits package (e.g., healthcare, dental and vision benefits, retirement savings account contributions, etc.).

Cleveland Clinic Health System is pleased to be an equal employment employer: Women / Minorities / Veterans / Individuals with Disabilities