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Job Description

The candidate will join the Institute for Translational Medicine & Pharmacology at the Icahn School of Medicine at Mount Sinai as an Associate Researcher I, contributing to cutting-edge research focused on T-cell plasticity, metabolic reprogramming, and immune fate decisions in health and disease.

She/he will play a central role in experimental studies aimed at understanding how metabolic signaling pathways and kinase activity regulate CD4⁺ T-cell stability, and transdifferentiation, with a particular emphasis on Treg, Th17, and hybrid T-cell states.

Qualifications

+ Bachelors or Masters degree in science or related field required

+ No experience required. One year of research experience preferred.

Responsibilities

+ Investigating T-cell plasticity through integrated metabolic, signaling, and functional studies using primary murine and human T cells.

+ Studying kinase-driven metabolic reprogramming in immune cells using genetically encoded and small-molecule fluorescent biosensors to monitor dynamic signaling and metabolic states at single-cell resolution.

+ Generating, breeding, and maintaining genetically modified mouse lines, including reporter, fate-mapping, and conditional knockout models, and overseeing the organization and health of the mouse colony.

+ Performing in vivo fate-mapping studies to track lineage stability and transdifferentiation of T-cell subsets under physiological and pathological conditions.

+ Conducting comprehensive immunological and molecular biology assays, including flow cytometry, multicolor immunophenotyping, cell sorting, Western blotting, qPCR, ELISA, and immunofluorescence microscopy.

+ Leading and executing studies in preclinical disease models, including solid organ transplantation models, experimental autoimmune encephalomyelitis (EAE), and additional models of autoimmunity and immune dysregulation.

+ Performing functional immune assays to assess T-cell suppressive capacity, activation, cytokine production, and metabolic fitness.

+ Analyzing and interpreting complex biological datasets in collaboration with computational and chemical biology teams.

+ Assisting with laboratory organization and operations, including experimental planning, reagent management, protocol optimization, and maintenance of shared laboratory resources.

+ This position will provide the Associate Researcher I with rigorous training at the interface of immunology, metabolism, and in vivo disease modeling, offering a strong platform for future advancement toward senior research roles, doctoral studies, or translational immunology careers in academia or industry.

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $58661 - $77125.98 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.