- ICON Clinical Research (Boston, MA)
- …into broader research objectives. Lead troubleshooting and optimization of antibody panels, fluorophore selection, and signal amplification strategies. Maintain ... experience. Proven expertise in multiplex immunofluorescence, including panel design, antibody validation, and image analysis. Hands-on experience with automated… more
- Bristol Myers Squibb (Cambridge, MA)
- …role. The ideal candidate is a scientific innovator with experience in antibody therapeutic engineering and optimization with a deep understanding of protein ... understanding of protein structure and function relationships Experience engineering antibody -based therapeutics to improve attributes such as activity, yield,… more
- AbbVie (Waltham, MA)
- …Development - Waltham is responsible for CMC analytical development activities for antibody drug conjugates (ADCs). We are building a team of highly skilled ... scientists and technical leaders in ADC development to drive the advancement of targeted cancer therapies to improve patient's lives. The Analytical Development- Waltham team is responsible for late-phase to commercial method development, optimization,… more
- Takeda Pharmaceuticals (Lexington, MA)
- …or tissue culture, preparation and screening of hybridomas for monoclonal antibody , polymerase chain reaction (PCR), liquid chromatography (LC), gas chromatography ... (GC), electrophoresis, mass spectrometry (MS), nuclear magnetic resonance (NMR), immunoassays, lyophilization, dynamic light scattering (DLS), UV-Vis spectroscopy, etc.; Troubleshoot throughout the process to improve analytical methods and enhance yield;… more
- American Red Cross (Dedham, MA)
- …Sequencing (NGS)** **.** **Platelet Serology** **and** **HLA Antibody Screening/Identification** **.** **Flow Cytometry Crossmatch** **Techniques.** **Chimerism ... Studies** **for transplantation monitoring and diagnostics.** **Strong focus on** **detail, accuracy, and efficiency** **in both scientific and customer-facing responsibilities.** **BMT, NGS, and Chimerism experience.** Proven track record of delivering… more
- AbbVie (Cambridge, MA)
- …documentation. Qualifications Basic Qualifications + PhD in Immunology, Immune-oncology, Antibody Engineering, Biochemistry, Molecular Biology, or a related field, ... with a strong background in cell surface protein biology and protein degradation mechanisms (summer and fall graduates are also welcome to apply). + Proven expertise in protein biochemistry and molecular biology, including experience with techniques such as… more
- AbbVie (Worcester, MA)
- …analytical development activities for biologic development, including mAbs, bispecifics, antibody -drug conjugates, and fusion proteins. + Expertise in protein and ... impurity analysis techniques such as HPLC, capillary electrophoresis, and other relevant methods. Experience with mass spectrometry and ELISA is a Plus. + Familiarity with USP/ICH guidelines for method development, qualification, and validation. Extensive… more
- Dana-Farber Cancer Institute (Boston, MA)
- Pre-clinical group developing next generation antibody and CAR T cell immunotherapies for cancer is looking for an exceptionally motivated individual with past in ... vivo experience. The Smith Lab group is focused CAR T cell immunotherapy for cancer and protein engineering/synthetic biology; taking projects from conception to transgene design /genetic engineering, through reduction to practice, and into in vivo studies,… more
- Takeda Pharmaceuticals (Boston, MA)
- …assay support to assess the functionality of Takeda's lead antibodies, antibody -drug conjugates, and related modalities against their intended targets, in disease ... areas spanning oncology, gastrointestinal, central nervous system, and rare diseases; develop biological functional assays to characterize antibodies for drug candidates; support lab automation; analyze data, interpret results, and present findings to project… more
- Takeda Pharmaceuticals (Boston, MA)
- …efforts, reagent or antigen protein production and characterization and/or antibody design, optimization and characterization + Work collaboratively and communicate ... clearly with interdisciplinary teams, including structural biologists, protein chemists, in vitro pharmacologists, medicinal and computational chemists, project management to advance pipeline projects + Clearly communicate protein production and… more