- Takeda Pharmaceuticals (Boston, MA)
- …of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, ... pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, similarity & diversity analysis. + Significant Industry experience contributing as Computational Chemist on drug discovery projects. + Strong Impact in progressing Discovery… more
- Frontier Medicines (Boston, MA)
- …and biologists to develop and refine structure-activity relationships (SAR), optimize molecular properties, and guide design hypotheses. + Contribute to project ... strategy and decision-making across all discovery stages, including target assessment, hit identification, lead optimization, and development candidate nomination. + Champion innovative computational tools and workflows, identify and implement emerging… more
- Beth Israel Lahey Health (Burlington, MA)
- …preparation, panel preparation, and run time on machine), biochemistry, and molecular biology are employed. Accurate record keeping and strain preservation are ... essential to the role. **Job Description:** **Essential Duties & Responsibilities** _including but not limited to:_ **Supervisory Controls:** + Works semi-independently on specific experiments after receiving directives from principal investigator. + Conducts… more
- Lilly (Boston, MA)
- …Profiling** : Develop comprehensive performance profiling across diverse molecular scaffolds, target classes, and property ranges, identifying systematic ... biases and failure modes. + **Platform Integration** : Collaborate with engineering teams to integrate validation frameworks with the TuneLab federated learning platform built on NVIDIA FLARE, ensuring scalable and automated testing across partner networks.… more
- Beth Israel Lahey Health (Boston, MA)
- …and/or cryo-EM, you will play a crucial role in unraveling the molecular mechanisms that underlie the regulation of triglyceride homeostasis. This position offers ... a stimulating and collaborative environment for scientific exploration. Key Responsibilities: . Conduct X-ray crystallography experiments to determine high-resolution structures of proteins involved in triglyceride metabolism. . Apply cryo-EM techniques for… more
- ThermoFisher Scientific (Worcester, MA)
- …lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar + **Assoc Scientist:** Previous experience that ... provides the knowledge, skills, and abilities to perform the job **(comparable to 0-2 years')** In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for… more
- Boston University (Boston, MA)
- …with post-mortem brain. In particular, the research will focus on deciphering the molecular mechanism of major AD risk variants as well as protective variants, ... associated genes and identifying targeted therapeutics. Furthermore, the research focusing on human iPSC-glial transplantation in AD animal models followed by in vivo electrophysiological and behavior readouts will enable potential stem cell therapeutics. The… more
- Pacific Northwest National Laboratory (Boston, MA)
- …Sciences, and Energy and Environment. In addition, we have an Environmental Molecular Sciences Laboratory, a Department of Energy, Office of Science user facility ... housed on the PNNL campus. The Energy and Environment Directorate delivers science and technology solutions for the nation's biggest energy and environmental challenges. Our more than 1,700 staff support the Department of Energy (DOE), delivering on key DOE… more
- ThermoFisher Scientific (Plainville, MA)
- …biochemical engineering, chemical engineering or related scientific field such as molecular biology, virology, biochemistry. Advanced degree preferred. + BS with 8+ ... years, Master's degree with 6+ years, or PhD with 3+ years' professional history. + Technical expertise in downstream biopharmaceutical manufacturing and/or process development. Experience with automated chromatography systems (AKTA) and automated tangential… more
- Harvard University (Cambridge, MA)
- …Harvard Medical School Department/Area Department of Biological Chemistry and Molecular Pharmacology Position Description We invite applicants for a postdoctoral ... fellow position in Devlin lab at Harvard Medical School in Boston, Massachusetts. The work of the Devlin lab is focused on understanding how the gut microbiome impacts human health and disease, with particular interest in identifying and investigating small… more