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PostDoctoral Associate

**Requisition Number:** 69123

**Location:** Boulder Colorado

**Employment Type:** Research Faculty

**Schedule:** Full Time

Posting Close Date:

Date Posted:

Job Summary

A Post-Doctoral Associate Position is available in the Park laboratory in the MCDB Department at University of Colorado-Boulder. We study functions and mechanisms of the proteasome, a molecular machine essential for cellular protein degradation. A prospective Post-Doctoral Fellow will investigate mechanisms of "novel spatial quality control" during proteasome assembly; see our recent paper in Nature Communications, 2025, https://www.nature.com/articles/s41467-025-58703-8 (https://apptrkr.com/get\_redirect.php?id=6797888&targetURL=http:// https://www.nature.com/articles/s41467-025-58703-8) . This new mechanism involves multiple cryptic nuclear localization signals, and evolutionarily conserved chaperones, including Gankyrin, a known onco-protein in humans. A prospective Post-Doctoral Associate will interrogate these mechanisms using biochemical and cell biological strategies, and actively participate in writing manuscripts. To learn more about our research, please refer to the website (https://www.colorado.edu/mcdb/soyeon-park (https://apptrkr.com/get\_redirect.php?id=6797888&targetURL=https://www.colorado.edu/mcdb/soyeon-park) ). CU is an Equal Opportunity Employer and complies with all applicable federal, state, and local laws governing nondiscrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity, and we encourage individuals from all backgrounds to apply, including protected veterans and individuals with disabilities.

Who We Are

Park lab in the Molecular, Cellular and Developmental Biology department at the University of Colorado Boulder.

( https://www.colorado.edu/mcdb/soyeon-park )

Dr. Park's laboratory studies the biogenesis of a molecular machine known as the proteasome, a major protease in eukaryotes. Her studies have changed the traditional view of the spontaneous formation of the proteasomal ATPase ring, via revealing conserved novel assembly chaperones for regulating assembly of the heterohexameric ATPase complex of the proteasome. These four chaperones (Rpn14, Nas6, Hsm3, and Nas2) principally act as negative regulators of proteasome assembly, by coupling with ATP hydrolysis. Her laboratory focuses on elucidating; (i) biological functions of active dissociation via these chaperones, (ii) mechanisms of an assembly-coupled degradation via an oncorpotein and assembly chaperone, Gankyrin in cancers, and (iii) signaling pathways for active disassembly of the proteasome via the chaperones during stress. Her work will provide major insights into the fundamental regulatory mechanisms for the proteasome and controlled protein degradation.

What Your Key Responsibilities Will Be

+ A prospective Post-Doctoral Associate will investigate mechanisms of "novel spatial quality control" during proteasome assembly. A prospective Post-Doctoral Associate will interrogate these mechanisms using biochemical and cell biological strategies, and actively participate in writing manuscripts.

What We Can Offer

$51,000 - $56,000 annually.

Benefits

At the University of Colorado Boulder (https://www.colorado.edu/) , we are committed to supporting the holistic health and well-being of our employees. Our comprehensive benefits package (https://www.colorado.edu/jobs/benefits) includes medical, dental, and retirement plans; generous paid time off; tuition assistance for you and your dependents; and an ECO Pass for local transit. As one of Boulder County's largest employers, CU Boulder offers an inspiring academic community and access to world-class outdoor recreation. Explore additional perks and programs through the CU Advantage (https://advantage.cu.edu/campus/cu-boulder) program.

Be Statements

Be ambitious. Be pioneering. Be Boulder.

What We Require

+ Ph.D. in Biology or related field.

Special Instructions

To apply, please submit the following materials:

1. Resume/CV

2. Cover Letter that addresses the following:

3. What is your current employment (if any), and why are you looking for a new position?

4. When are you available to start a new position?

5. Describe your ideal work environment and the work schedule.

6. Describe your experimental laboratory experience in detail.

7. What are your short and long-term professional goals?

During the application process you will need to enter contact information for a reference. We will request a letter of recommendation and additional materials, if needed, as the search progresses.

If you are selected as the finalist, your degree will be verified by the CU Boulder Campus Human Resources department using an approved online vendor. If your degree was obtained outside of the United States, please submit a translated version (if applicable) as an optional attachment.

For full consideration, please apply by **December 19th, 2024.** The position will remain open until filled.

Note: Application materials will not be accepted via email. For consideration, please apply through CU Boulder Jobs. (https://www.colorado.edu/jobs/)

In compliance with the Colorado Job Application Fairness Act, in any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

To apply, visit https://jobs.colorado.edu/jobs/JobDetail/PostDoctoral-Associate/69123 (https://apptrkr.com/6797888)

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The University of Colorado does not discriminate on the basis of race, color, national origin, sex, age, pregnancy, disability, creed, religion, sexual orientation, gender identity, gender expression, veteran status, political affiliation, or political philosophy. All qualified individuals are encouraged to apply.