• Senior Principal Research Scientist/Director

    AbbVie (North Chicago, IL)


    Company Description

    AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok (https://www.tiktok.com/@abbvie) .

    Job Description

    Purpose:

    The Senior Principal Research Scientist/Director of Drug Metabolism and Disposition (Biotransformation) will lead the biotransformation activities within the Drug Metabolism and Disposition department. This role aims to provide strategic direction, ensure high-quality data, and support the advancement of drug discovery and development through expert understanding of drug metabolism, pharmacokinetics, and biotransformation processes.

    Responsibilities:

    + Lead a team of scientists in designing and executing biotransformation studies, including both nonclinical and clinical studies.

    + Develop and implement strategic plans for drug metabolism and biotransformation to support drug discovery and development projects.

    + Serve as a subject matter expert to cross-functional teams, integrating in vitro and in vivo data for the understanding of absorption, distribution, metabolism, excretion (ADME), and pharmacokinetics.

    + Ensure regulatory compliance for all studies and reports, providing oversight of radiolabeled and non-radiolabeled studies.

    + Communicate findings and strategies clearly to project teams and management, both orally and through written reports.

    + Collaborate with internal and external partners to ensure the timely and high-quality delivery of study data.

    + Mentor and supervise junior scientists and laboratory staff, fostering an inclusive and empowering work environment.

    + Contribute to scientific knowledge through conference presentations and publication of new research findings.

    + Develop and maintain a research budget in alignment with organizational goals.

    + Stay abreast of industry trends and advancements in drug metabolism and biotransformation methodologies.

    Qualifications

    Qualifications:

    + Bachelor’s Degree in Science with 18 years of related work; Master’s Degree Science or PharmD with 16 years of related work; PhD in Science or related field with 10 years of related work experience in drug metabolism and biotransformation.

    + Demonstrated expertise in metabolite identification and ADME studies from discovery through IND/NDA submissions and regulatory interactions.

    + Strong leadership, communication, and interpersonal skills.

    + Experience with regulatory requirements for drug development.

    + Deep understanding of ADME and PK/PD science, experience with both small molecules and biologics.

    + Strong fundamental understanding of mass spectrometry and its strategic use for metabolite profiling and structural determination.

    + Proficient in the use of advanced analytical techniques such as MS-Imaging and NMR

    + Knowledge of developing role-based training plans and maintaining scientific rigor in training methodologies.

    + Experience managing and mentoring teams within a dynamic research environment.

     

    Additional Information

     

    Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

     

    + The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

    + We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

    + This job is eligible to participate in our short-term incentive programs. ​

    + This job is eligible to participate in our long-term incentive programs​

     

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    Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

     

    AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

     

    US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

    US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

    https://www.abbvie.com/join-us/reasonable-accommodations.html