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TOP SKILLS PER MGR:

1. LC/MS experience /oligo method development

2. Mass Spec Maintenance and trouble shooting

3. Oligonucleotide Purification

Job Description:

Seeking a highly motivated Associate Scientist II to join the Oligonucleotide Chemistry Team in Lexington, Massachusetts. The candidate will be responsible for analysis and purification of oligonucleotides. This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms. Prior experience in LCMS method development and oligonucleotide purification and characterization is desired.

Relationships:

This position reports to the Director, Oligonucleotide Chemistry as an individual contributor. Daily interaction with other peers in oligo synthesis, medicinal chemistry and biology teams in support of early phase product pipeline.

Essential Functions:

+ Primary responsibility to provide analytical lab support for Oligonucleotide early phase pipeline

+ Development of robust LC/MS, IPRP and SAX analytical methods for analysis and purification of highly modified oligonucleotide drug substances.

+ Prepare analytical samples, analyze and process data, primarily by UPLC, LC-MS

+ Operate, maintain and troubleshoot lab instruments

+ Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides and sgRNA

+ Keep accurate records of the experiments and summarize the results in well communicated presentations or written reports

+ Purification, deprotection, annealing and lyophilization of oligonucleotides to support all disease programs

+ Oligonucleotide synthesis

+ Possess excellent written and verbal communication skills

+ Conduct laboratory work in an efficient manner that ensures a safe working environment

Qualifications:

+ MS or BS with 3+ years of industrial experience

+ Strong knowledge of mass spectrometry and purification techniques

+ Experience with waters LC/MS instruments preferred

+ Experience with purification and LC/MS analysis of sgRNA highly preferred

+ Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation

+ Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics

+ Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent, Waters and/or Thermo UHPLC’s and associated software

+ In depth knowledge of GLP/GMP’s in a pharmaceutical environment

+ The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams

Education:

+ Bachelor's degree

About US Tech Solutions:

US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To learn more about US Tech Solutions, please visit www.ustechsolutions.com.

US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.