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Job Title: Sr. Scientist

Compensation: $37.45- $43.86

Type: Contract

Overview

Leading pharmaceutical company looking for a Sr. Scientist. Ideal candidates should have a PhD or equivalent experience in bioanalytical chemistry, analytical chemistry, pharmaceutical sciences, or a related discipline with recognized and established expertise in mass spectrometry. Additionally 4+ years of research experience in the biotech/pharmaceutical industry or closely related academic areas.

Responsibilities

+ Determine and develop novel and appropriate LC-MS methods for the characterization of intact ADCs, antibodies, and other proteins

+ Develop and optimize both broadly applicable and fit-for-purpose methodologies for the capture, characterization, and quantification of proteins and conjugates from biological samples

+ Perform peptide mapping to deeply characterize proteins and bioconjugates

+ Provide care, maintenance, and troubleshooting of shared LC-MS instrumentation, including training new users and developing and maintaining best practices

+ Provide technical and scientific advice and support to scientists of all levels, advise on LC and mass spectrometry related questions, and provide sample processing and data analysis for non-MS users

+ Practice continuous improvement to refine methods and optimize processes, staying in touch with relevant literature and state of the art technologies

+ Maintain strong communication and collaborative relationships with mass spectrometry groups outside of Research

+ Create and organize technical information to deliver effective presentations in multiple forums

Requirements

EDUCATION AND EXPERIENCE:

+ A Ph.D. or equivalent experience in bioanalytical chemistry, analytical chemistry, pharmaceutical sciences, or a related discipline with recognized and established expertise in mass spectrometry

+ 4+ years of research experience in the biotech/pharmaceutical industry or closely related academic areas

+ Demonstrated experience in the operation and maintenance of mass spectrometers, their software, and applicable data analysis software

+ Established capability in biological characterization and data analysis, specifically utilizing mass spectrometry techniques

+ Attention to detail and a strong analytical mindset capable of proposing sound experimental strategies and developing new LC-MS protocols

+ Uses critical thinking to solve complex problems, address challenges, overcome obstacles, and anticipate areas for growth

+ Established safe laboratory skills and accurate record keeping

+ Ability to work independently on routine experiments

TECHNICAL SKILLS REQUIREMENTS:

Preferred qualifications include:

+ Hands-on experience working with a Waters Xevo G2S QTof, Thermofisher Q Exactive, and/or SCIEX X500B QTOF

+ Familiarity with affinity purification of proteins, peptides and/or metabolites.

+ Experience analyzing all types of recombinant proteins

+ Experience identifying and characterizing post-translational modifications or enzymatic modifications of proteins

+ Experience with protein conformational analysis, such as Hydrogen deuterium exchange mass spectrometry

+ Familiarity with Protein Metrics software and reporting, including high throughput data processing

+ Experience or familiarity with mass spectrometry automation

+ Knowledge of SEC-MALS biological analysis methods

Benefits

System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.

Ref: #558-Scientific

System One, and its subsidiaries including Joulé, ALTA IT Services, CM Access, TPGS, and MOUNTAIN, LTD., are leaders in delivering workforce solutions and integrated services across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible full-time employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.